Elevated insulin sensitivity and beta-cell function during pregnancy in mothers of growth-restricted newborns (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Elevated insulin sensitivity and beta-cell function during pregnancy in mothers of growth-restricted newborns (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1152/ajpendo.00024.2011 (literal)

Alternative label

• Dalfrà, M.G.;Pacini, G.;Parretti, E.;Ragazzi, E.;Mello, G.;Lapolla, A., (2011)
  Elevated insulin sensitivity and beta-cell function during pregnancy in mothers of growth-restricted newborns
  in American journal of physiology: endocrinology and metabolism
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Dalfrà, M.G.;Pacini, G.;Parretti, E.;Ragazzi, E.;Mello, G.;Lapolla, A., (literal)

Pagina inizio

• E25 (literal)

Pagina fine

• E30 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/21467301 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 301 (literal)

Rivista

• American journal of physiology: endocrinology and metabolism (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1, 6: Department of Medical and Surgical Sciences, University of Padua; 2: Metabolic Unit, Institute of Biomedical Engineering,National Research Council, Padua; 3, 5: Department of Gynecology, Perinatology, and Human Reproduction, University of Florence, Florence; 4: Department of Pharmacology and Anesthesiology, University of Padua, Padua, Italy (literal)

Titolo

• Elevated insulin sensitivity and beta-cell function during pregnancy in mothers of growth-restricted newborns (literal)

Abstract

• Dalfra MG, Pacini G, Parretti E, Ragazzi E, Mello G, Lapolla A. Elevated insulin sensitivity and beta-cell function during pregnancy in mothers of growth-restricted newborns. Am J Physiol Endocrinol Metab 301: E25-E30, 2011. First published April 5, 2011; doi: 10.1152/ajpendo.00024.2011.-The \"Barker hypothesis\" suggests that low birth weight might predict future risk of developing obesity, cardiovascular disease, and type 2 diabetes. Identification of the causes of fetal growth restriction (FGR) is critical for preventive and management strategies. Some studies indicate that maternal carbohydrate metabolism might be involved in FGR development. We aimed to evaluate, in a large number of normotensive pregnant women with normal glucose tolerance, the effect of insulin sensitivity and beta-cell function on unexplained fetal growth. A total of 1,814 Caucasian pregnant women with normal prepregnancy body mass index were tested with a 75-g, 2-h glucose load (24-28 gestation wk). Insulin sensitivity was evaluated with fasting (QUICKI) and dynamic index (OGIS) and beta-cell function with a modified insulinogenic index as Delta AUC(insulin)/Delta AUC(glucose) and disposition index. FGR was a birth weight below the 5th percentile for gestational age. FGR developed in 99 (5.5%) pregnant women that showed significantly higher QUICKI, OGIS, insulinogenic, and disposition index with respect to women with normal-weight babies (P < 0.0001). By using multiple regression analysis in the FRG group, QUICKI and OGIS appeared as significant independent variables (P < 0.0001 and P < 0.0366, respectively). We conclude that elevated insulin sensitivity seems to be one of the factors involved in determining unexplained fetal growth retardation; its assessment, even only in the fasting state, could be useful to guide any possible monitoring and therapeutic strategies to reduce fetal complications. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Institute of biomedical engineering (ISIB) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR

• GIOVANNI PACINI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Elevated insulin sensitivity and beta-cell function during pregnancy in mothers of growth-restricted newborns" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• GIOVANNI PACINI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• American journal of physiology: endocrinology and metabolism (Rivista)

Insieme di parole chiave di

• Parole chiave di "Elevated insulin sensitivity and beta-cell function during pregnancy in mothers of growth-restricted newborns" (Insieme di parole chiave)