Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2337/db10-1806 (literal)

Alternative label

• Bonnet, F.;Ducluzeau, P.H.;Gastaldelli, A.;Laville, M.;Anderwald, C.H.;Konrad, T.;Mari, A.;Balkau, B., (2011)
  Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women
  in Diabetes (N.Y.N.Y.); American Diabetes Association, Alexandria (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bonnet, F.;Ducluzeau, P.H.;Gastaldelli, A.;Laville, M.;Anderwald, C.H.;Konrad, T.;Mari, A.;Balkau, B., (literal)

Pagina inizio

• 1660 (literal)

Pagina fine

• 1667 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/21521874 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 60 (literal)

Rivista

• Diabetes (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• [ 1 ] Univ Rennes 1, Ctr Hosp Univ CHU Rennes, Serv Endocrinol Diabetol, INSERM,UMR 991, Rennes, France [ 2 ] CHU Angers, Serv Endocrinol Diabetol, Angers, France [ 3 ] Natl Res Ctr CNR, Inst Clin Physiol, Cardiometab Risk Unit, Pisa, Italy [ 4 ] Ctr Rech Nutr Humaine, CRNH Rhone Alpes, INSERM, INRA,U 870 1235, Lyon, France [ 5 ] Med Univ Vienna, Dept Internal Med 3, Clin Div Endocrinol & Metab, Vienna, Austria [ 6 ] Goethe Univ Frankfurt, Acad Teaching Inst, Med Fac Johann Wolfgang Goethe, Inst Metab Res, Frankfurt, Germany [ 7 ] Inst Biomed Engn, Padua, Italy [ 8 ] Ctr Rech Epidemiol & Sante Populat CESP, INSERM, U1018, Villejuif, France [ 8 ] Univ Paris 11, UMRS 1018, Villejuif, France (literal)

Titolo

• Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women (literal)

Abstract

• OBJECTIVE: The pathophysiological mechanisms to explain the association between risk of type 2 diabetes and elevated concentrations of gamma-glutamyltransferase (GGT) and alanineaminotransferase (ALT) remain poorly characterized. We explored the association of liver enzymes with peripheral and hepatic insulin resistance, insulin secretion, insulin clearance, and glucagon concentration. RESEARCH DESIGN AND METHODS: We studied 1,309 nondiabetic individuals from the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study; all had a euglycemic-hyperinsulinemic clamp and an oral glucose tolerance test (OGTT) with assessment of insulin secretion and hepatic insulin extraction. The hepatic insulin resistance index was calculated in 393 individuals. RESULTS: In both men and women, plasma concentrations of GGT and ALT were inversely related with insulin sensitivity (M/I) (all P < 0.01). Likewise, the hepatic insulin resistance index was positively correlated with both GGT (r = 0.37, P < 0.0001, men; r = 0.36, P < 0.0001, women) and ALT (r = 0.25, P = 0.0005, men; r = 0.18, P = 0.01, women). These associations persisted in multivariable models. Increased GGT and ALT were significantly associated with higher insulin secretion rates and with both reduced endogenous clearance of insulin and hepatic insulin extraction during the OGTT (P = 0.0005 in men; P = 0.003 in women). Plasma fasting glucagon levels increased over ALT quartiles (men, quartile 4 vs. quartile 1 11.2 +/- 5.1 vs. 9.3 +/- 3.8 pmol/L, respectively, P = 0.0002; women, 9.0 +/- 4.3 vs. 7.6 +/- 3.1, P = 0.001). CONCLUSIONS: In healthy individuals, increased GGT and ALT were biomarkers of both systemic and hepatic insulin resistance with concomitant increased insulin secretion and decreased hepatic insulin clearance. The novel finding of a positive correlation between ALT and fasting glucagon level concentrations warrants confirmation in type 2 diabetes. (literal)

Editore

• American Diabetes Association (Editore)

Prodotto di

• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)
• Istituto di fisiologia clinica (IFC) (Istituto)
• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)
• Institute of biomedical engineering (ISIB) (Istituto)

Autore CNR

• ANDREA MARI (Unità di personale interno)
• AMALIA GASTALDELLI (Persona)

Insieme di parole chiave

• Parole chiave di "Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Istituto di fisiologia clinica (IFC) (Istituto)
• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• AMALIA GASTALDELLI (Persona)
• ANDREA MARI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetes (Rivista)

Editore di

• American Diabetes Association (Editore)

Insieme di parole chiave di

• Parole chiave di "Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women" (Insieme di parole chiave)