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Shape of glucose, insulin, C-peptide curves during a three hour oral glucose tolerance test: any relationship with the degree of glucose tolerance? (Articolo in rivista)
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- Shape of glucose, insulin, C-peptide curves during a three hour oral glucose tolerance test: any relationship with the degree of glucose tolerance? (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1152/ajpregu.00650.2010. (literal)
- Alternative label
Tura, A.;Morbiducci, U.;Sbrignadello, S.;Winhofer, Y.;Pacini, G.;Kautzky-Willer, A. (2011)
Shape of glucose, insulin, C-peptide curves during a three hour oral glucose tolerance test: any relationship with the degree of glucose tolerance?
in American journal of physiology. Regulatory, integrative and comparative physiology
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Tura, A.;Morbiducci, U.;Sbrignadello, S.;Winhofer, Y.;Pacini, G.;Kautzky-Willer, A. (literal)
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- http://www.ncbi.nlm.nih.gov/pubmed/21248305 (literal)
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- ISI Web of Science (WOS) (literal)
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- 1, 3, 5: Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy;
2: Department of Mechanics,Politecnico di Torino, Torino, Italy;
4, 6: Department of Internal Medicine III, Division of Endocrinology and Metabolism,
Medical University of Vienna, Vienna, Austria (literal)
- Titolo
- Shape of glucose, insulin, C-peptide curves during a three hour oral glucose tolerance test: any relationship with the degree of glucose tolerance? (literal)
- Abstract
- Shape of glucose, insulin, C-peptide curves during a 3-h
oral glucose tolerance test: any relationship with the degree of glucose
tolerance? Am J Physiol Regul Integr Comp Physiol 300: R941-R948, 2011.
First published January 11, 2011; doi:10.1152/ajpregu.00650.2010.--We
aimed to analyze the shape of the glucose, insulin, and C-peptide curves
during a 3-h oral glucose tolerance test (OGTT). Another aim was defining
an index of shape taking into account the whole OGTT pattern. Five-hundred
ninety-two OGTT curves were analyzed, mainly from women with former
gestational diabetes, with glycemic concentrations characterized by normal
glucose tolerance (n ? 411), impaired glucose metabolism (n ? 134), and
Type 2 diabetes (n ? 47). Glucose curves were classified according to their
shape (monophasic, biphasic, triphasic, and 4/5-phases), and the metabolic
condition of the subjects, divided according to the glucose shape stratification,
was analyzed. Indices of shape based on the discrete second-order
derivative of the curve patterns were also defined. We found that the majority
of the glucose curves were monophasic (n ? 262). Complex shapes were less
frequent but not rare (n ? 37 for the 4/5-phases shape, i.e., three peaks).
There was a tendency toward the amelioration of the metabolic condition for
increasing complexity of the shape, as indicated by lower glucose concentrations,
improved insulin sensitivity and -cell function. The shape index
computed on C-peptide, WHOSHCP (WHole-Ogtt-SHape-index-C-peptide),
showed a progressive increase [monophasic: 0.93 0.04 (dimensionless);
4/5-phases: 1.35 0.14], and it showed properties typical of -cell
function indices. We also found that the type of glucose shape is often
associated to similar insulin and C-peptide shape. In conclusion, OGTT
curves can be characterized by high variability, and complex OGTT shape is
associated with better glucose tolerance. WHOSHCP (WHole-Ogtt-SHapeindex)
may be a powerful index of -cell function much simpler than
model-based indices.
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