Shape of glucose, insulin, C-peptide curves during a three hour oral glucose tolerance test: any relationship with the degree of glucose tolerance? (Articolo in rivista)

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Label
  • Shape of glucose, insulin, C-peptide curves during a three hour oral glucose tolerance test: any relationship with the degree of glucose tolerance? (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1152/ajpregu.00650.2010. (literal)
Alternative label
  • Tura, A.;Morbiducci, U.;Sbrignadello, S.;Winhofer, Y.;Pacini, G.;Kautzky-Willer, A. (2011)
    Shape of glucose, insulin, C-peptide curves during a three hour oral glucose tolerance test: any relationship with the degree of glucose tolerance?
    in American journal of physiology. Regulatory, integrative and comparative physiology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Tura, A.;Morbiducci, U.;Sbrignadello, S.;Winhofer, Y.;Pacini, G.;Kautzky-Willer, A. (literal)
Pagina inizio
  • R941 (literal)
Pagina fine
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/21248305 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 300 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1, 3, 5: Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy; 2: Department of Mechanics,Politecnico di Torino, Torino, Italy; 4, 6: Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria (literal)
Titolo
  • Shape of glucose, insulin, C-peptide curves during a three hour oral glucose tolerance test: any relationship with the degree of glucose tolerance? (literal)
Abstract
  • Shape of glucose, insulin, C-peptide curves during a 3-h oral glucose tolerance test: any relationship with the degree of glucose tolerance? Am J Physiol Regul Integr Comp Physiol 300: R941-R948, 2011. First published January 11, 2011; doi:10.1152/ajpregu.00650.2010.--We aimed to analyze the shape of the glucose, insulin, and C-peptide curves during a 3-h oral glucose tolerance test (OGTT). Another aim was defining an index of shape taking into account the whole OGTT pattern. Five-hundred ninety-two OGTT curves were analyzed, mainly from women with former gestational diabetes, with glycemic concentrations characterized by normal glucose tolerance (n ? 411), impaired glucose metabolism (n ? 134), and Type 2 diabetes (n ? 47). Glucose curves were classified according to their shape (monophasic, biphasic, triphasic, and 4/5-phases), and the metabolic condition of the subjects, divided according to the glucose shape stratification, was analyzed. Indices of shape based on the discrete second-order derivative of the curve patterns were also defined. We found that the majority of the glucose curves were monophasic (n ? 262). Complex shapes were less frequent but not rare (n ? 37 for the 4/5-phases shape, i.e., three peaks). There was a tendency toward the amelioration of the metabolic condition for increasing complexity of the shape, as indicated by lower glucose concentrations, improved insulin sensitivity and -cell function. The shape index computed on C-peptide, WHOSHCP (WHole-Ogtt-SHape-index-C-peptide), showed a progressive increase [monophasic: 0.93 0.04 (dimensionless); 4/5-phases: 1.35 0.14], and it showed properties typical of -cell function indices. We also found that the type of glucose shape is often associated to similar insulin and C-peptide shape. In conclusion, OGTT curves can be characterized by high variability, and complex OGTT shape is associated with better glucose tolerance. WHOSHCP (WHole-Ogtt-SHapeindex) may be a powerful index of -cell function much simpler than model-based indices. sha (literal)
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