Nonpulsed sinusoidal electromagnetic fields as a noninvasive strategy in bone repair: the effect on human mesenchymal stem cell osteogenic differentiation. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Nonpulsed sinusoidal electromagnetic fields as a noninvasive strategy in bone repair: the effect on human mesenchymal stem cell osteogenic differentiation. (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1089/ten.TEC.2014.0216 (literal)

Alternative label

• Ledda M, D'Emilia E, Giuliani L, Marchese R, Foletti A, Grimaldi S, Lisi A. (2015)
  Nonpulsed sinusoidal electromagnetic fields as a noninvasive strategy in bone repair: the effect on human mesenchymal stem cell osteogenic differentiation.
  in Tissue engineering. Part C Methods
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ledda M, D'Emilia E, Giuliani L, Marchese R, Foletti A, Grimaldi S, Lisi A. (literal)

Pagina inizio

• 207 (literal)

Pagina fine

• 217 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• Tissue engineering. Part C Methods (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)
• PubMed (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Translational Pharmacology , National Research Council, Rome, Italy . Dipartimento Insediamenti produttivi ed Interazione con l'Ambiente (INAIL-DIPIA), Rome, Italy. Research Center, FBF S. Peter Hospital, Rome, Italy (literal)

Titolo

• Nonpulsed sinusoidal electromagnetic fields as a noninvasive strategy in bone repair: the effect on human mesenchymal stem cell osteogenic differentiation. (literal)

Abstract

• In vivo control of osteoblast differentiation is an important process needed to maintain the continuous supply of mature osteoblast cells for growth, repair, and remodeling of bones. The regulation of this process has also an important and significant impact on the clinical strategies and future applications of cell therapy. In this article, we studied the effect of nonpulsed sinusoidal electromagnetic field radiation tuned at calcium-ion cyclotron frequency of 50 Hz exposure treatment for bone differentiation of human mesenchymal stem cells (hMSCs) alone or in synergy with dexamethasone, their canonical chemical differentiation agent. Five days of continuous exposure to calcium-ion cyclotron resonance affect hMSC proliferation, morphology, and cytoskeletal actin reorganization. By quantitative real-time polymerase chain reaction, we also observed an increase of osteoblast differentiation marker expression such as Runx2, alkaline phosphatase (ALP), osteocalcin (OC), and osteopontin (OPN) together with the osteoprotegerin mRNA modulation. Moreover, in these cells, the increase of the protein expression of OPN and ALP was also demonstrated. These results demonstrate bone commitment of hMSCs through a noninvasive and biocompatible differentiating physical agent treatment and highlight possible applications in new regenerative medicine protocols. (literal)

Prodotto di

• La Risonanza di ciclotrone come strategia per la veicolazione e il rilascio di farmaci (ME.P06.031.001) (Modulo)
• Sviluppo di protocolli per il differenziamento di cellule staminali tramite interazione tra frequenze di risonanza di ciclotrone di ioni e biosistemi (ME.P06.031.003) (Modulo)

Autore CNR

• ANTONELLA LISI (Unità di personale interno)
• MARIO LEDDA (Persona)
• SETTIMIO GRIMALDI (Persona)

Incoming links:

Autore CNR di

• ANTONELLA LISI (Unità di personale interno)
• MARIO LEDDA (Persona)
• SETTIMIO GRIMALDI (Persona)

Prodotto

• La Risonanza di ciclotrone come strategia per la veicolazione e il rilascio di farmaci (ME.P06.031.001) (Modulo)
• Sviluppo di protocolli per il differenziamento di cellule staminali tramite interazione tra frequenze di risonanza di ciclotrone di ioni e biosistemi (ME.P06.031.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Tissue engineering. Part C Methods (Rivista)