18F-FDG PET/CT, 99mTc-MIBI, and MRI in the Prediction of Outcome of Patients With Multiple Myeloma: A Comparative Study (Articolo in rivista)

Type
Label
  • 18F-FDG PET/CT, 99mTc-MIBI, and MRI in the Prediction of Outcome of Patients With Multiple Myeloma: A Comparative Study (Articolo in rivista) (literal)
Anno
  • 2015-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1097/RLU.0000000000000696 (literal)
Alternative label
  • Fonti, Rosa; Pace, Leonardo; Cerchione, Claudio; Catalano, Lucio; Salvatore, Barbara; De Luca, Serena; Pane, Fabrizío; Salvatore, Marco; Del Vecchio, Silvana (2015)
    18F-FDG PET/CT, 99mTc-MIBI, and MRI in the Prediction of Outcome of Patients With Multiple Myeloma: A Comparative Study
    in Clinical nuclear medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Fonti, Rosa; Pace, Leonardo; Cerchione, Claudio; Catalano, Lucio; Salvatore, Barbara; De Luca, Serena; Pane, Fabrizío; Salvatore, Marco; Del Vecchio, Silvana (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/record/display.url?eid=2-s2.0-84921505117&origin=inward (literal)
Rivista
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IBB-CNR, Università di Salerno, Università Federico II di Napoli, Università Federico II di Napoli, IBB-CNR, Università Federico II di Napoli, Università Federico II di Napoli, IRCCS-SDN, Università Federico II di Napoli. (literal)
Titolo
  • 18F-FDG PET/CT, 99mTc-MIBI, and MRI in the Prediction of Outcome of Patients With Multiple Myeloma: A Comparative Study (literal)
Abstract
  • PURPOSE: The aim of this study was to compare the relative contribution of F-FDG PET/CT, Tc-MIBI, and MRI in predicting progression-free survival (PFS) and overall survival (OS) in multiple myeloma (MM) patients.,PATIENTS AND METHODS: Thirty-three newly diagnosed MM patients had been evaluated in a previous study by F-FDG PET/CT, Tc-MIBI, and spine and pelvis MRI reporting focal lesions and diffuse bone marrow involvement. Twenty-seven patients were then subjected to a mean follow-up period of 58 months, whereas 6 patients were lost.,RESULTS: F-FDG PET/CT, Tc-MIBI, and MRI were positive in 26, 24, and 22 patients, respectively, showing diffuse bone marrow involvement in 12, 21, and 17 patients and a total of 185, 56, and 39 focal lesions, respectively. At follow-up, 18 patients showed complete or partial remission, whereas 9 patients developed progressive disease, 7 of which died of myeloma. Univariate and subsequent multivariate analysis showed that F-FDG PET/CT focal uptake and Tc-MIBI focal and diffuse uptake predicted PFS (P = 0.0006), whereas F-FDG PET/CT focal uptake and Tc-MIBI focal uptake predicted OS (P = 0.0010). Although MRI diffuse pattern predicted PFS at univariate analysis (P = 0.0376), it was not retained in the model at multivariate analysis. Receiver operating characteristic curve analysis showed that the number of focal lesions best discriminating for PFS and OS prediction was 4 and 11 for F-FDG PET/CT and 2 in both cases for Tc-MIBI, respectively. By Kaplan-Meier analysis and log-rank testing, PFS and OS at follow-up were significantly better in patients showing a number of focal lesions at F-FDG PET/CT or Tc-MIBI lower than the respective cutoff (P = 0.03, P = 0.004, and P < 0.0001, respectively). Finally, PFS was significantly better in patients showing absent/faint diffuse Tc-MIBI uptake than in those having moderate/intense diffuse uptake (P = 0.0012).,CONCLUSIONS: F-FDG PET/CT and Tc-MIBI may be useful in predicting PFS and OS in myeloma patients. (literal)
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