Chronic peripheral hyperinsulinemia in type 1 diabetic patients after successful combined pancreas-kidney transplantation does not affect ectopic lipid accumulation in skeletal muscle and liver (Articolo in rivista)

Type
Label
  • Chronic peripheral hyperinsulinemia in type 1 diabetic patients after successful combined pancreas-kidney transplantation does not affect ectopic lipid accumulation in skeletal muscle and liver (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.2337/db09-0354 (literal)
Alternative label
  • Stadler, M.; Anderwald, C. ;Pacini, G.; Zbyn, S.; Promintzer-Schifferl, M.; Mandl, M.; Bischof, M.; Gruber, S.; Nowotny, P.; Luger, A.; Prager, R.; Krebs, M. (2010)
    Chronic peripheral hyperinsulinemia in type 1 diabetic patients after successful combined pancreas-kidney transplantation does not affect ectopic lipid accumulation in skeletal muscle and liver
    in Diabetes (N.Y.N.Y.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Stadler, M.; Anderwald, C. ;Pacini, G.; Zbyn, S.; Promintzer-Schifferl, M.; Mandl, M.; Bischof, M.; Gruber, S.; Nowotny, P.; Luger, A.; Prager, R.; Krebs, M. (literal)
Pagina inizio
  • 215 (literal)
Pagina fine
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 59 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1, 11: Hietzing Hospital, 3rd Medical Department of Metabolic Diseases and Nephrology, Vienna, Austria - Karl Landsteiner Institute of Metabolic Diseases and Nephrology, Vienna, Austria/ 2: Medical University of Vienna, Department of Internal Medicine III, Division of Endocrinology and Metabolism, Vienna, Austria/ 3: Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy/ 4, 8: Medical University of Vienna, Department of Radiology, MR Center-High Field MR, Vienna, Austria/ 5, 6, 7, 9, 10, 12: Medical University of Vienna, Department of Internal Medicine III, Division of Endocrinology and Metabolism, Vienna, Austria (literal)
Titolo
  • Chronic peripheral hyperinsulinemia in type 1 diabetic patients after successful combined pancreas-kidney transplantation does not affect ectopic lipid accumulation in skeletal muscle and liver (literal)
Abstract
  • OBJECTIVE: So far it is unclear whether chronic peripheral hyperinsulinemia per se might contribute to ectopic lipid accumulation and consequently insulin resistance. We investigated the effects of systemic instead of portal insulin release in type 1 diabetic patients after successful pancreas-kidney transplantation (PKT) with systemic venous drainage on the intracellular lipid content in liver and soleus muscle, endogenous glucose production (EGP), and insulin sensitivity. RESEARCH DESIGN AND METHODS: In nine PKT patients and nine matching nondiabetic control subjects, intrahepatocellular lipids (IHCLs) and intramyocellular lipids (IMCLs) were measured using (1)H nuclear magnetic resonance spectroscopy. Fasting EGP was measured using d-[6,6-(2)H(2)]glucose tracer dilution. A 3-h 75-g oral glucose tolerance test (OGTT) allowed us to assess kinetics of glucose, free fatty acids, insulin, and C-peptide concentrations in plasma and to calculate the clamp-like index (CLIX) for insulin sensitivity and the hepatic insulin resistance (HIR) index. RESULTS: The PKT patients displayed approximately twofold increased fasting insulin (20 +/- 6 vs. 9 +/- 3 microU/ml; P < 0.0002) compared with that in nondiabetic control subjects and approximately 10% increased fasting glucose (P < 0.02) concentrations, but during the OGTT areas under the concentration curves of C-peptide and insulin were similar. IHCL (PKT, 2.9 +/- 2.5%; nondiabetic control subjects, 4.4 +/- 6.6%), IMCL (PKT, 1.0 +/- 0.4%; nondiabetic control subjects, 1.0 +/- 0.5%), CLIX (PKT, 8 +/- 2; nondiabetic control subjects, 7 +/- 3), HIR (PKT, 25.6 +/- 13.2; nondiabetic control subjects, 35.6 +/- 20 [mg * min(-1) * kg(-1)] x [microU/ml]), and EGP (PKT, 1.6 +/- 0.2; nondiabetic control subjects, 1.7 +/- 0.2 mg * min(-1) * kg(-1)) were comparable between PKT patients and nondiabetic control subjects. IHCL was negatively correlated with CLIX in all participants (r = -0.55; P < 0.04). CONCLUSIONS: Despite fasting peripheral hyperinsulinemia because of systemic venous drainage, type 1 diabetic patients after PKT show similar IHCL, IMCL, insulin sensitivity, and fasting EGP in comparison with nondiabetic control subjects. These results suggest that systemic hyperinsulinemia per se does not cause ectopic lipid accumulation in liver and skeletal muscle. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it