HLA-DRB1*13:01 allele in the genetic susceptibility to colorectal carcinoma (Articolo in rivista)

Type
Label
  • HLA-DRB1*13:01 allele in the genetic susceptibility to colorectal carcinoma (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/ijc.29285 (literal)
Alternative label
  • Anna Aureli1, Angelica Canossi1, Tiziana Del Beato1, Luana Franceschilli2, Oreste Buonomo2, Franco Papola3, Flavio De Sanctis2, Giulia Lanzilli1, Pierpaolo Sileri2, Andrea Coppola4, Sara Caratelli1, Roberto Arriga4, Augusto Orlandi5, Davide Lauro4, Piero Rossi2 and Giuseppe Sconocchia1 (2014)
    HLA-DRB1*13:01 allele in the genetic susceptibility to colorectal carcinoma
    in International journal of cancer (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Anna Aureli1, Angelica Canossi1, Tiziana Del Beato1, Luana Franceschilli2, Oreste Buonomo2, Franco Papola3, Flavio De Sanctis2, Giulia Lanzilli1, Pierpaolo Sileri2, Andrea Coppola4, Sara Caratelli1, Roberto Arriga4, Augusto Orlandi5, Davide Lauro4, Piero Rossi2 and Giuseppe Sconocchia1 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 23 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 5 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • october (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 CNR Institute of Translational Pharmacology, Rome and L'Aquila, Italy 2 Department of Experimental Medicine and Surgery, The University of Rome, Tor Vergata, Italy 3 Immunohematology and Tissue Typing Regional Center S. Salvatore Hospital, L'Aquila, Italy 4 Department of Systems Medicine, The University of Rome, Tor Vergata, Italy 5 Department of Biomedicine and Prevention, The University of Rome, Tor Vergata, Italy (literal)
Titolo
  • HLA-DRB1*13:01 allele in the genetic susceptibility to colorectal carcinoma (literal)
Abstract
  • What's new? Altered expression of the HLA-DRB1 antigen, a key player in the immune response, is linked to colorectal cancer with a background of ulcerative colitis. But it is unknown whether HLA-DRB1 alleles affect risk of colorectal tumor development, and their impact in the absence of inflammatory bowel disease remains relatively unexplored. In this study, 29 distinct HLA-DRB1 alleles were identified in colorectal cancer patients and normal controls. One allele, DRB1*13:01, was found to be significantly associated with increased risk of colorectal tumor, suggesting that it may be a marker for colorectal cancer outside the setting of inflammatory bowel disease. (literal)
  • Increasing evidence suggests that HLA-DRB1 alleles reduce or increase the risk of developing ulcerative colitis-associated colorectal carcinoma (CRC) tumors. However, the role of HLA-DRB1 locus on the susceptibility to develop CRC tumor, in the absence of a history of inflammatory bowel diseases (IBDs), is unclear. The aim of our study was to determine whether HLA-DRB1 alleles are associated with IBD-independent CRC tumor. HLA-DRB1 allele polymorphisms were identified by sequence-based typing method in 53 CRC patients and 57 sex- and age-matched healthy Caucasian controls. Pearson's chisquared analysis with Yate's correction or Fisher's exact test with Bonferroni's correction, as appropriate, were used to compare the allele frequency (AF) differences of HLA-DRB1 in patients and controls. A total of 29 HLA-DRB1 alleles were recognized. A detailed study of these alleles allowed to identify DRB1*13:01 and DRB1*11:01 alleles that were significantly associated with an increased and reduced risk to develop CRC tumor, respectively. AF of DRB1*13:01, in CRC patients, was significantly higher than that of healthy controls, even following Bonferroni's correction (p50.029). In contrast, the presence of the DRB1*11:01 allele was negatively associated with CRC tumor as evidenced by the significantly lower AF in CRC patients than that of healthy controls (p50.005). However, following Bonferroni's correction, the AF of DRB*11:01 lost its statistical significance. These results suggest that HLA-DRB1*13:01 allele could be a potential marker for predicting genetic susceptibility to CRC tumor. In contrast, the protective role of DRB1*11:01 remains unclear. (literal)
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it