http://www.cnr.it/ontology/cnr/individuo/prodotto/ID304505

The distribution of KIR-HLA functional blocks is different from North to South of Italy (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

The distribution of KIR-HLA functional blocks is different from North to South of Italy (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1111/tan.12299 (literal)

Alternative label

Fasano, M. E.; Rendine, S.; Pasi, A.; Bontadini, A.; Cosentini, E.; Carcassi, C.; Capittini, C.; Cornacchini, G.; de Arias, A. Espadas; Garbarino, L.; Carella, G.; Mariotti, M. L.; Mele, L.; Miotti, V.; Moscetti, A.; Nesci, S.; Ozzella, G.; Piancatelli, D.; Porfirio, B.; Riva, M. R.; Romeo, G.; Tagliaferri, C.; Lombardo, C.; Testi, M.; Amoroso, A.; Martinetti, M. (2014)
The distribution of KIR-HLA functional blocks is different from North to South of Italy
in Tissue antigens
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Fasano, M. E.; Rendine, S.; Pasi, A.; Bontadini, A.; Cosentini, E.; Carcassi, C.; Capittini, C.; Cornacchini, G.; de Arias, A. Espadas; Garbarino, L.; Carella, G.; Mariotti, M. L.; Mele, L.; Miotti, V.; Moscetti, A.; Nesci, S.; Ozzella, G.; Piancatelli, D.; Porfirio, B.; Riva, M. R.; Romeo, G.; Tagliaferri, C.; Lombardo, C.; Testi, M.; Amoroso, A.; Martinetti, M. (literal)

Pagina inizio

168 (literal)

Pagina fine

173 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

83 (literal)

Rivista

Tissue antigens (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

3 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Hosp Citta Salute Sci; University of Turin; IRCCS Policlin San Matteo Fdn; St Orsola Marcello Malpighi Hosp; University of Naples Federico II; University of Cagliari; Osped Niguarda Ca Granda; Fdn IRCCS Ca Granda Osped Maggiore Policlin; Galliera Hosp; Spedali Civil Brescia; Cisanello Hosp; SS Antonio & Biagio Hosp; Transfus Serv S Maria Misericordia Hosp; S Camillo Forlanini Hosp; AO Osped Riuniti Marche Nord; San Camillo Forlanini Hosp; Consiglio Nazionale delle Ricerche (CNR); University of Florence; S Gerardo Hosp; Bianchi Melacrino Morelli Hosp; S Bortolo Hosp; Fondazione IRCCS Istituto Nazionale Tumori Milan; Polyclin Tor Vergata (literal)

Titolo

The distribution of KIR-HLA functional blocks is different from North to South of Italy (literal)

Abstract

The killer cell immunoglobulin-like receptor (KIR)-human leukocyte antigen (HLA) interaction represents an example of genetic epistasis, where the concomitant presence of specific genes or alleles encoding receptor-ligand units is necessary for the activity of natural killer (NK) cells. Although KIR and HLA genes segregate independently, they co-evolved under environmental pressures to maintain particular KIR-HLA functional blocks for species survival. We investigated, in 270 Italian healthy individuals, the distribution of KIR and HLA polymorphisms in three climatic areas (from cold north to warm south), to verify their possible geographical stratification. We analyzed the presence of 13 KIR genes and genotyped KIR ligands belonging to HLA class I: HLA-C, HLA-B and HLA-A. We did not observe any genetic stratification for KIR genes and HLA-C ligands in Italy. By contrast, in a north-to-south direction, we found a decreasing trend for the HLA-A3 and HLA-A11 ligands (P = 0.012) and an increasing trend for the HLA-B ligands carrying the Bw4 epitope (P = 0.0003) and the Bw4 Ile80 epitope (P = 0.0005). The HLA-A and HLA-B KIR ligands were in negative linkage disequilibrium (correlation coefficient -0.1211), possibly as a consequence of their similar function in inhibiting NK cells. The distribution of the KIR-HLA functional blocks was different along Italy, as we observed a north-to-south ascending trend for KIR3DL1, when coupled with HLA-B Bw4 ligands (P = 0.0067) and with HLA-B Bw4 Ile80 (P = 0.0027), and a descending trend for KIR3DL2 when coupled with HLA-A3 and HLA-A11 ligands (P = 0.0044). Overall, people from South Italy preferentially use the KIR3DL1-HLA-B Bw4 functional unit, while those from the North Italy equally use both the KIR3DL2-HLA-A3/A11 and the KIR3DL1-HLA-B Bw4 functional units to fight infections. Thus, only KIR3DL receptors, which exert the unique role of microbial sensors through the specific D0 domain, and their cognate HLA-A and HLA-B ligands are selectively pressured in Italy according to geographical north-to-south distribution. (literal)

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