http://www.cnr.it/ontology/cnr/individuo/prodotto/ID304410
Single Photon Emission Computed Tomography Striatal Asymmetry Index May Predict Dopaminergic Responsiveness in Parkinson Disease (Articolo in rivista)
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- Label
- Single Photon Emission Computed Tomography Striatal Asymmetry Index May Predict Dopaminergic Responsiveness in Parkinson Disease (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1097/WNF.0b013e318211f945 (literal)
- Alternative label
Contrafatto, Donatella; Mostile, Giovanni; Nicoletti, Alessandra; Raciti, Loredana; Luca, Antonina; Dibilio, Valeria; Lanzafame, Salvatore; Distefano, Angela; Drago, Filippo; Zappia, Mario (2011)
Single Photon Emission Computed Tomography Striatal Asymmetry Index May Predict Dopaminergic Responsiveness in Parkinson Disease
in Clinical neuropharmacology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Contrafatto, Donatella; Mostile, Giovanni; Nicoletti, Alessandra; Raciti, Loredana; Luca, Antonina; Dibilio, Valeria; Lanzafame, Salvatore; Distefano, Angela; Drago, Filippo; Zappia, Mario (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- University of Catania; Consiglio Nazionale delle Ricerche (CNR); University of Catania (literal)
- Titolo
- Single Photon Emission Computed Tomography Striatal Asymmetry Index May Predict Dopaminergic Responsiveness in Parkinson Disease (literal)
- Abstract
- Objectives: Parkinson disease (PD) is a neurodegenerative disorder, characterized by the excellent response to L-dopa and by asymmetry of neurological signs. The aim of the present study is to investigate a possible relationship between responsiveness to L-dopa in patients with PD and asymmetry detected by single photon emission computed tomography (SPECT) with [(123)I]FP-CIT (DaTSCAN). (literal)
- Methods: We performed a retrospective study in 20 patients with PD never previously exposed to L-dopa, who had undergone (1) a short-term L-dopa test with L-dopa/carbidopa 250/25 mg to quantify dopaminergic responsiveness, and (2) a SPECT with DaTSCAN to assess the degree of nigrostriatal neuronal degeneration. We estimated the magnitude and the duration of the response to L-dopa test as well as the striatal asymmetry index (SAI) detected by SPECT with DaTSCAN. (literal)
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