beta-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform for entrapment of guanine-based drugs (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• beta-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform for entrapment of guanine-based drugs (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Alternative label

• Iannazzo, Daniela; Mazzaglia, Antonino; Scala, Angela; Pistone, Alessandro; Galvagno, Signorino; Lanza, Maurizio; Riccucci, Cristina; Ingo, Gabriel Maria; Colao, Ivana; Sciortino, Maria Teresa; Valle, Francesco; Piperno, Anna; Grassi, Giovanni (2014)
  beta-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform for entrapment of guanine-based drugs
  in Colloids and surfaces. B, Biointerfaces (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Iannazzo, Daniela; Mazzaglia, Antonino; Scala, Angela; Pistone, Alessandro; Galvagno, Signorino; Lanza, Maurizio; Riccucci, Cristina; Ingo, Gabriel Maria; Colao, Ivana; Sciortino, Maria Teresa; Valle, Francesco; Piperno, Anna; Grassi, Giovanni (literal)

Pagina inizio

• 264 (literal)

Pagina fine

• 270 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 123 (literal)

Rivista

• Colloids and surfaces. B, Biointerfaces (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ Messina; Univ Messina; Consiglio Nazl Ric CNR IPCF; Consiglio Nazl Ric CNR ISMN; Univ Messina; Consiglio Nazl Ric CNR ISMN; Univ Messina (literal)

Titolo

• beta-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform for entrapment of guanine-based drugs (literal)

Abstract

• The design of beta-cyclodextrin/multiwalled carbon nanotubes hybrid (beta-CD-MWCNT) as nanoplatform for the entrapment and delivery of guanine based drugs is described here. The functionalized carbon nanomaterials have been characterized by XPS spectroscopy, electron microscopy (FEG-SEM and TEM), AFM, TGA, and FT-IR to achieve insights on structure, morphology and chemical composition. The drug binding abilities of nanocarrier towards the guanine (G) and Acyclovir (Acy) were proved by UV-vis and DSC experiments. Host-guest equilibrium association constants and drug loading have been evaluated for G/beta-CD-MWCNT and Acy/beta-CD-MWCNT complexes. The release studies showed a sustained delivery of Acy without initial burst effect confirming a strong interaction of drug with the nanoplatform sites. The preliminary antiviral data indicated that the Acyclovir loaded into the beta-CD-MWCNT platform interferes with HSV-1 replication and the antireplicative effect was higher than the free drug. (C) 2014 Elsevier B.V. All rights reserved. (literal)

Prodotto di

• Nanotecnologie di materiali multifunzionali e sistemi biologici (PM.P05.010.001) (Modulo)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)

Autore CNR

• CRISTINA RICCUCCI (Persona)
• GABRIEL MARIA INGO (Unità di personale interno)
• ANGELA SCALA (Persona)
• ANTONINO MAZZAGLIA (Unità di personale interno)
• FRANCESCO VALLE (Persona)

Insieme di parole chiave

• Parole chiave di "beta-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform for entrapment of guanine-based drugs" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Nanotecnologie di materiali multifunzionali e sistemi biologici (PM.P05.010.001) (Modulo)

Autore CNR di

• ANTONINO MAZZAGLIA (Unità di personale interno)
• GABRIEL MARIA INGO (Unità di personale interno)
• FRANCESCO VALLE (Persona)
• ANGELA SCALA (Persona)
• CRISTINA RICCUCCI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Colloids and surfaces. B, Biointerfaces (Rivista)

Insieme di parole chiave di

• Parole chiave di "beta-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform for entrapment of guanine-based drugs" (Insieme di parole chiave)