http://www.cnr.it/ontology/cnr/individuo/prodotto/ID304112
DNA-protein interaction dynamics at the Lamin B2 replication origin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973337 (Articolo in rivista)
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- DNA-protein interaction dynamics at the Lamin B2 replication origin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973337 (Articolo in rivista) (literal)
- Anno
- 2015-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.4161/15384101.2014.973337 (literal)
- Alternative label
Puzzi L, Marchetti L, Peverali FA, Biamonti G, Giacca M. (2015)
DNA-protein interaction dynamics at the Lamin B2 replication origin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973337
in Cell cycle (Georget. Tex.)
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- Puzzi L, Marchetti L, Peverali FA, Biamonti G, Giacca M. (literal)
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- Scuola Normale Superiore di Pisa; International Centre for Genetic Engineering and Biotechnology; Istituto di Genetica Molecolare, CNR, Pavia, Italy. (literal)
- Titolo
- DNA-protein interaction dynamics at the Lamin B2 replication origin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973337 (literal)
- Abstract
- To date, a complete understanding of the molecular events leading to DNA replication origin activation in mammalian cells still remains elusive. In this work, we report the results of a high resolution chromatin immunoprecipitation study to detect proteins interacting with the human Lamin B2 replication origin. In addition to the pre-RC component ORC4 and to the transcription factors USF and HOXC13, we found that 2 components of the AP-1 transcription factor, c-Fos and c-Jun, are also associated with the origin DNA during the late G1 phase of the cell cycle and that these factors interact with ORC4. Both DNA replication and AP-1 factor binding to the origin region were perturbed by cell treatment with merbarone, a topoisomerase II inhibitor, suggesting that DNA topology is essential for determining origin function. (literal)
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