Prognostic role of 18F-FDG PET/CT in the postoperative evaluation of differentiated thyroid cancer patients (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Prognostic role of 18F-FDG PET/CT in the postoperative evaluation of differentiated thyroid cancer patients (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1097/RLU.0000000000000621 (literal)

Alternative label

• Pace L.; Klain M.; Salvatore B.; Nicolai E.; Zampella E.; Assante R.; Pellegrino T.; Storto G.; Fonti R.; Salvatore M. (2015)
  Prognostic role of 18F-FDG PET/CT in the postoperative evaluation of differentiated thyroid cancer patients
  in Clinical nuclear medicine
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pace L.; Klain M.; Salvatore B.; Nicolai E.; Zampella E.; Assante R.; Pellegrino T.; Storto G.; Fonti R.; Salvatore M. (literal)

Pagina inizio

• 111 (literal)

Pagina fine

• 115 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84921468312&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 40 (literal)

Rivista

• Clinical nuclear medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Salerno, Italy; Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli Federico II, Napoli, Italy; Istituto di Biostrutture e Bioimmagini, CNR, Via Tommaso De Amicis 95, Napoli, 80145, Italy; IRCSS SDN, Napoli, Italy; IRCSS CROB, Rionero in Vulture, Italy (literal)

Titolo

• Prognostic role of 18F-FDG PET/CT in the postoperative evaluation of differentiated thyroid cancer patients (literal)

Abstract

• PURPOSE:The aim of this study was to evaluate the role of F-FDG PET/CT performed after surgery but before radioiodine therapy in patients with differentiated thyroid cancer. PROCEDURES:FDG PET/CT was performed off l-thyroxine in 60 newly diagnosed differentiated thyroid cancer patients. Clinical and hematological evaluation as well as high-resolution neck ultrasound were performed. All patients underwent a complete follow-up (range, 6-67 months; mean [SD], 31.7 [20.6] months). The date of recurrence or the most recent office visit was recorded. Progression-free survival (PFS) is the primary end point of this study. Analysis was performed by Cox proportional hazards model. Survival curves were generated using Kaplan-Meier estimates, and the log-rank test was used to assess significance. RESULTS:FDG PET/CT was negative in 63% of patients, 20% had FDG thyroid bed uptake, 5% distant metastases, and 12% lymph node FDG uptake. In patients with positive FDG PET/CT scan (ie, those with distant metastases or lymph node uptake), a higher rate of recurrence was observed (50% vs 6%, P < 0.05). Thyroglobulin, neck ultrasound, stage, and FDG PET/CT correlated with PFS at univariate analysis. At multivariate analysis, only thyroglobulin and FDG PET/CT continued to be predictors of PFS. Patients with a negative FDG PET/CT scan have a better PFS either in the whole group or in those with elevated thyroglobulin level (both >2 ng/mL and >10 ng/mL). CONCLUSIONS:FDG PET/CT was abnormal in 17% of patients. Moreover, FDG PET/CT has an independent prognostic role, with a better PFS in patients with a negative scan. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• BARBARA SALVATORE (Unità di personale interno)
• ROSA FONTI (Unità di personale interno)
• TERESA PELLEGRINO (Unità di personale interno)
• GIOVANNI STORTO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Prognostic role of 18F-FDG PET/CT in the postoperative evaluation of differentiated thyroid cancer patients" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ROSA FONTI (Unità di personale interno)
• GIOVANNI STORTO (Unità di personale interno)
• TERESA PELLEGRINO (Unità di personale interno)
• BARBARA SALVATORE (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Clinical nuclear medicine (Rivista)

Insieme di parole chiave di

• Parole chiave di "Prognostic role of 18F-FDG PET/CT in the postoperative evaluation of differentiated thyroid cancer patients" (Insieme di parole chiave)