RGDechi-hCit: alpha v beta 3 Selective Pro-Apoptotic Peptide as Potential Carrier for Drug Delivery into Melanoma Metastatic Cells (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• RGDechi-hCit: alpha v beta 3 Selective Pro-Apoptotic Peptide as Potential Carrier for Drug Delivery into Melanoma Metastatic Cells (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1371/journal.pone.0106441 (literal)

Alternative label

• Capasso, Domenica; de Paola, Ivan; Liguoro, Annamaria; Del Gatto, Annarita; Di Gaetano, Sonia; Guarnieri, Daniela; Saviano, Michele; Zaccaro, Laura (2014)
  RGDechi-hCit: alpha v beta 3 Selective Pro-Apoptotic Peptide as Potential Carrier for Drug Delivery into Melanoma Metastatic Cells
  in PloS one
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Capasso, Domenica; de Paola, Ivan; Liguoro, Annamaria; Del Gatto, Annarita; Di Gaetano, Sonia; Guarnieri, Daniela; Saviano, Michele; Zaccaro, Laura (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• PloS one (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 9 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Naples Federico II; Consiglio Nazionale delle Ricerche (CNR); Scarl; CRIB Italian Inst Technol; Consiglio Nazionale delle Ricerche (CNR) (literal)

Titolo

• RGDechi-hCit: alpha v beta 3 Selective Pro-Apoptotic Peptide as Potential Carrier for Drug Delivery into Melanoma Metastatic Cells (literal)

Abstract

• alpha v beta 3 integrin is an important tumor marker widely expressed on the surface of cancer cells. Recently, we reported some biological features of RGDechi-hCit, an alpha v beta 3 selective peptide antagonist. In the present work, we mainly investigated the pro-apoptotic activity of the molecule and its ability to penetrate the membrane of WM266 cells, human malignant melanoma cells expressing high levels of alpha v beta 3 integrin. For the first time we demonstrated the pro-apoptotic effect and the ability of RGDechi-hCit to enter into cell overexpressing alpha v beta 3 integrin mainly by clathrin- and caveolin-mediated endocytosis. Furthermore, we deepened and confirmed the selectivity, anti-adhesion, and anti-proliferative features of the peptide. Altogether these experiments give insight into the biological behavior of RGDechi-hCit and have important implications for the employment of the peptide as a new selective carrier to deliver drugs into the cell and as a therapeutic and diagnostic tool for metastatic melanoma. Moreover, since the peptide shows a pro-apoptotic effect, a great perspective could be the development of a new class of selective systems containing RGDechi-hCit and pro-apoptotic molecules or other therapeutic agents to attain a synergic action. (literal)

Prodotto di

• Institute of Crystallography (IC) (Istituto)
• Applicazione di tecniche cristallografiche e modellistica computazionale per studi strutturali di biomolecole (PM.P01.023.005) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• LAURA ZACCARO (Persona)
• MICHELE SAVIANO (Persona)
• ANNARITA DEL GATTO (Persona)
• SONIA DI GAETANO (Unità di personale interno)

Incoming links:

Autore CNR di

• SONIA DI GAETANO (Unità di personale interno)
• MICHELE SAVIANO (Persona)
• LAURA ZACCARO (Persona)
• ANNARITA DEL GATTO (Persona)

Prodotto

• Institute of Crystallography (IC) (Istituto)
• Institute of biostructure and bioimaging (IBB) (Istituto)
• Applicazione di tecniche cristallografiche e modellistica computazionale per studi strutturali di biomolecole (PM.P01.023.005) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)