Insulin sensitivity, fat distribution and adipocytokine response to different diets in lean, and obese cats before and after weight loss (Articolo in rivista)

Type
Label
  • Insulin sensitivity, fat distribution and adipocytokine response to different diets in lean, and obese cats before and after weight loss (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1152/ajpregu.00313.2006 (literal)
Alternative label
  • Hoenig M, Thomaseth K, Waldron M and Ferguson D, (2007)
    Insulin sensitivity, fat distribution and adipocytokine response to different diets in lean, and obese cats before and after weight loss
    in American journal of physiology. Regulatory, integrative and comparative physiology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Hoenig M, Thomaseth K, Waldron M and Ferguson D, (literal)
Pagina inizio
  • R227 (literal)
Pagina fine
  • R234 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 292 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1,4 - Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, Georgia 2 - Institute of Biomedical Engineering of the Italian National Research Council, Padua, Italy 3 - Nestle Purina Research, St. Louis, Missouri (literal)
Titolo
  • Insulin sensitivity, fat distribution and adipocytokine response to different diets in lean, and obese cats before and after weight loss (literal)
Abstract
  • Obesity is a major health problem in cats and a risk factor for diabetes. It has been postulated that cats are always gluconeogenic and that the rise in obesity might be related to high dietary carbohydrates. We examined the effect of a high-carbohydrate/low-protein (HC) and a high-protein/ low-carbohydrate (HP) diet on glucose and fat metabolism during euglycemic hyperinsulinemic clamp, adipocytokines, and fat distribu- tion in 12 lean and 16 obese cats before and after weight loss. Feeding diet HP led to greater heat production in lean but not in obese cats. Regardless of diet, obese cats had markedly decreased glucose effec- tiveness and insulin resistance, but greater suppression of nonesteri- fied fatty acids during the euglycemic hyperinsulinemic clamp was seen in obese cats on diet HC compared with lean cats on either diet or obese cats on diet HP. In contrast to humans, obese cats had abdominal fat equally distributed subcutaneously and intra-abdomi- nally. Weight loss normalized insulin sensitivity; however, increased nonesterified fatty acid suppression was maintained and fat loss was less in cats on diet HC. Adiponectin was negatively and leptin positively correlated with fat mass. Lean cats and cats during weight loss, but not obese cats, adapted to the varying dietary carbohydrate/ protein content with changes in substrate oxidation. We conclude that diet HP is beneficial through maintenance of normal insulin sensitivity of fat metabolism in obese cats, facilitating the loss of fat during weight loss, and increasing heat production in lean cats. These data also show that insulin sensitivity of glucose and fat metabolism can be differentially regulated in cats. (literal)
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