http://www.cnr.it/ontology/cnr/individuo/prodotto/ID30383
Insulin sensitivity, fat distribution and adipocytokine response to different diets in lean, and obese cats before and after weight loss (Articolo in rivista)
- Type
- Label
- Insulin sensitivity, fat distribution and adipocytokine response to different diets in lean, and obese cats before and after weight loss (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1152/ajpregu.00313.2006 (literal)
- Alternative label
Hoenig M, Thomaseth K, Waldron M and Ferguson D, (2007)
Insulin sensitivity, fat distribution and adipocytokine response to different diets in lean, and obese cats before and after weight loss
in American journal of physiology. Regulatory, integrative and comparative physiology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Hoenig M, Thomaseth K, Waldron M and Ferguson D, (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1,4 - Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, Georgia
2 - Institute of Biomedical Engineering of the Italian National Research Council, Padua, Italy
3 - Nestle Purina Research, St. Louis, Missouri (literal)
- Titolo
- Insulin sensitivity, fat distribution and adipocytokine response to different diets in lean, and obese cats before and after weight loss (literal)
- Abstract
- Obesity is a major health problem in cats and a risk factor for diabetes. It has been
postulated that cats are always gluconeogenic and that the rise in
obesity might be related to high dietary carbohydrates. We examined
the effect of a high-carbohydrate/low-protein (HC) and a high-protein/
low-carbohydrate (HP) diet on glucose and fat metabolism during
euglycemic hyperinsulinemic clamp, adipocytokines, and fat distribu-
tion in 12 lean and 16 obese cats before and after weight loss. Feeding
diet HP led to greater heat production in lean but not in obese cats.
Regardless of diet, obese cats had markedly decreased glucose effec-
tiveness and insulin resistance, but greater suppression of nonesteri-
fied fatty acids during the euglycemic hyperinsulinemic clamp was
seen in obese cats on diet HC compared with lean cats on either diet
or obese cats on diet HP. In contrast to humans, obese cats had
abdominal fat equally distributed subcutaneously and intra-abdomi-
nally. Weight loss normalized insulin sensitivity; however, increased
nonesterified fatty acid suppression was maintained and fat loss was
less in cats on diet HC. Adiponectin was negatively and leptin
positively correlated with fat mass. Lean cats and cats during weight
loss, but not obese cats, adapted to the varying dietary carbohydrate/
protein content with changes in substrate oxidation. We conclude that
diet HP is beneficial through maintenance of normal insulin sensitivity
of fat metabolism in obese cats, facilitating the loss of fat during
weight loss, and increasing heat production in lean cats. These data
also show that insulin sensitivity of glucose and fat metabolism can be
differentially regulated in cats. (literal)
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