Influence of Hyperinsulinemia and Insulin Resistance on In Vivo beta-Cell Function Their Role in Human beta-Cell Dysfunction (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Influence of Hyperinsulinemia and Insulin Resistance on In Vivo beta-Cell Function Their Role in Human beta-Cell Dysfunction (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2337/db11-0827 (literal)

Alternative label

• Mari, A.;Tura, A.;Natali, A.;Anderwald, C.;Balkau, B.;Lalic, N.;Walker, M.;Ferrannini, E., (2011)
  Influence of Hyperinsulinemia and Insulin Resistance on In Vivo beta-Cell Function Their Role in Human beta-Cell Dysfunction
  in Diabetes (N.Y.N.Y.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mari, A.;Tura, A.;Natali, A.;Anderwald, C.;Balkau, B.;Lalic, N.;Walker, M.;Ferrannini, E., (literal)

Pagina inizio

• 3141 (literal)

Pagina fine

• 3147 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/22028180 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 60 (literal)

Rivista

• Diabetes (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 12 (literal)

Note

• ISI Web of Science (WoS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1, 2: National Research Council Institute of Biomedical Engineering, Padova, Italy; 3, 8: Department of Internal Medicine, University of Pisa, Pisa, Italy; 4: National Research Council Institute of Biomedical Engineering, Padova, Italy / Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; 5: INSERM U258, Villejuif, France; 6: Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia; 7: Department of Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K. (literal)

Titolo

• Influence of Hyperinsulinemia and Insulin Resistance on In Vivo beta-Cell Function Their Role in Human beta-Cell Dysfunction (literal)

Abstract

• RESEARCH DESIGN AND METHODS-Insulin sensitivity (by euglycemic clamp), insulin-induced secretory response at iso-glycemia (HSR) (as C-peptide percent change from basal during the clamp), glucose-induced secretory response (GISR) to an intravenous glucose bolus, and beta-cell glucose sensitivity (beta-GS) (by oral glucose tolerance test [OGTT] modeling) were measured in 1,151 NGT and 163 IGR subjects from the RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) study. (literal)
• OBJECTIVE-Recent work has shown that insulin stimulates its own secretion in insulin-sensitive humans, suggesting that insulin resistance in the beta-cell could cause beta-cell dysfunction. We have tested whether insulin exposure and insulin sensitivity modulate beta-cell function in subjects with normal glucose tolerance (NGT) and whether they contribute to dysglycemia in impaired glucose regulation (IGR). (literal)

Prodotto di

• Institute of biomedical engineering (ISIB) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• ANDREA TURA (Unità di personale interno)
• ANDREA MARI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• ANDREA MARI (Unità di personale interno)
• ANDREA TURA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetes (Rivista)