In vivo targeting of cutaneous melanoma using an melanoma stimulating hormone-engineered human protein cage with fluorophore and magnetic resonance imaging tracers (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• In vivo targeting of cutaneous melanoma using an melanoma stimulating hormone-engineered human protein cage with fluorophore and magnetic resonance imaging tracers (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1166/jbn.2015.1946 (literal)

Alternative label

• Vannucci, Luca E.; Falvo, Elisabetta; Failla, Cristina Maria; Carbo, Miriam; Fornara, Manuela; Canese, Rossella; Cecchetti, Serena; Rajsiglova, Lenka; Stakheev, Dmitry; K?í?an, Jiri; Boffi, Alberto; Carpinelli, Giulia; Morea, Veronica; Ceci, Pierpaolo (2015)
  In vivo targeting of cutaneous melanoma using an melanoma stimulating hormone-engineered human protein cage with fluorophore and magnetic resonance imaging tracers
  in Journal of biomedical nanotechnology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vannucci, Luca E.; Falvo, Elisabetta; Failla, Cristina Maria; Carbo, Miriam; Fornara, Manuela; Canese, Rossella; Cecchetti, Serena; Rajsiglova, Lenka; Stakheev, Dmitry; K?í?an, Jiri; Boffi, Alberto; Carpinelli, Giulia; Morea, Veronica; Ceci, Pierpaolo (literal)

Pagina inizio

• 81 (literal)

Pagina fine

• 92 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/record/display.url?eid=2-s2.0-84918545084&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 11 (literal)

Rivista

• Journal of biomedical nanotechnology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Microbiology of the Academy of Sciences of the Czech Republic; CNR - National Research Council of Italy, Institute of Molecular Biology and Pathology; IRCCS Istituto Dermopatico dell'Immacolata; Universita degli Studi di Roma La Sapienza; Istituto Superiore Di Sanita, Rome; Istituto Italiano di Tecnologia (literal)

Titolo

• In vivo targeting of cutaneous melanoma using an melanoma stimulating hormone-engineered human protein cage with fluorophore and magnetic resonance imaging tracers (literal)

Abstract

• Nanoparticle (NP)-based materials are promising agents for enhancing cancer diagnosis and treatment. Once functionalized for selective targeting of tumor-expressed molecules, they can specifically deliver drugs and diagnostic molecules inside tumor cells. In the present work, we evaluated the in vivo melanoma-targeting ability of a nanovector (HFt-MSHPEG) based on human protein ferritin (HFt), functionalized with both melanoma-targeting melanoma stimulating hormone (?-MSH) and stabilizing poly(ethylene glycol) (PEG) molecules. Independent and complementary techniques, such as whole-specimen confocal microscopy and magnetic resonance imaging, were used to detect in vivo localization of NP constructs with suitable tracers (i.e., fluorophores or magnetic metals). Targeted HFt-MSH-PEG NPs accumulated persistently at the level of primary melanoma and with high selectivity with respect to other organs. Melanoma localization of untargeted HFt-PEG NPs, which lack the ?-MSH moiety, was less pronounced. Furthermore, HFt-MSH-PEG NPs accumulated to a significantly lower extent and with a different distribution in a diverse type of tumor (TS/A adenocarcinoma), which does not express ?-MSH receptors. Finally, in a spontaneous lung metastasis model, HFt-MSH-PEG NPs localized at the metastasis level as well. These results suggest that HFt-MSH-PEG NPs are suitable carriers for selective in vivo delivery of diagnostic or therapeutic agents to cutaneous melanoma. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Analisi di famiglie proteiche e predizione strutturale di proteine modello (SV.P18.004.002) (Modulo)

Autore CNR

• VERONICA MOREA (Unità di personale interno)
• PIERPAOLO CECI (Persona)

Insieme di parole chiave

• Keywords of "In vivo targeting of cutaneous melanoma using an melanoma stimulating hormone-engineered human protein cage with fluorophore and magnetic resonance imaging tracers" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Analisi di famiglie proteiche e predizione strutturale di proteine modello (SV.P18.004.002) (Modulo)

Autore CNR di

• VERONICA MOREA (Unità di personale interno)
• PIERPAOLO CECI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of biomedical nanotechnology (Rivista)

Insieme di parole chiave di

• Keywords of "In vivo targeting of cutaneous melanoma using an melanoma stimulating hormone-engineered human protein cage with fluorophore and magnetic resonance imaging tracers" (Insieme di parole chiave)