Cysteine co-oxidation process driven by native peptide folding: an example on HER2 receptor model system (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Cysteine co-oxidation process driven by native peptide folding: an example on HER2 receptor model system (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00726-014-1681-7 (literal)

Alternative label

• Calce, Enrica; Sandomenico, Annamaria; Saviano, Michele; Ruvo, Menotti; De Luca, Stefania (2014)
  Cysteine co-oxidation process driven by native peptide folding: an example on HER2 receptor model system
  in Amino acids (Wien, Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Calce, Enrica; Sandomenico, Annamaria; Saviano, Michele; Ruvo, Menotti; De Luca, Stefania (literal)

Pagina inizio

• 1197 (literal)

Pagina fine

• 1206 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 46 (literal)

Rivista

• Amino acids (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Consiglio Nazionale delle Ricerche (CNR); CIRPeB; Consiglio Nazionale delle Ricerche (CNR) (literal)

Titolo

• Cysteine co-oxidation process driven by native peptide folding: an example on HER2 receptor model system (literal)

Abstract

• Synthetic models of receptors that have relevant biological roles are valuable tools for studying receptors itself and the corresponding ligands. Their properties can be validated at first by their capacity to fold in solution under native-like conditions and to assume conformations structurally and functionally equivalent to those in the native receptor. In this context, a new strategy to prepare the two-fragments synthetic receptor model HER2-DIVMP, an independent structural and functional motif of HER2, has been developed and the folding properties have been investigated. The strategy is based on a one-step cysteine co-oxidation procedure in slightly alkaline aqueous buffers, whereby the two separate peptide chains are allowed to self-assemble in solution. Under these conditions, the two chains spontaneously form the expected heterodimer with the correct pattern of disulfide bridges. To gain insights on the folding mechanism, we investigated the folding of two scrambled variants of the constituent peptide chains. (literal)

Prodotto di

• Institute of Crystallography (IC) (Istituto)

Autore CNR

• ANNAMARIA SANDOMENICO (Unità di personale interno)
• STEFANIA DE LUCA (Unità di personale interno)
• MENOTTI RUVO (Unità di personale interno)
• MICHELE SAVIANO (Persona)

Insieme di parole chiave

• Keywords of "Cysteine co-oxidation process driven by native peptide folding: an example on HER2 receptor model system" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• STEFANIA DE LUCA (Unità di personale interno)
• MICHELE SAVIANO (Persona)
• MENOTTI RUVO (Unità di personale interno)
• ANNAMARIA SANDOMENICO (Unità di personale interno)

Prodotto

• Institute of Crystallography (IC) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Amino acids (Rivista)

Insieme di parole chiave di

• Keywords of "Cysteine co-oxidation process driven by native peptide folding: an example on HER2 receptor model system" (Insieme di parole chiave)