(E)-2-Cyano-3-(5?-piperidin-1-yl-2,2?-bithien-5-yl)acrylic acid: A fluorescent probe for detecting prefibrillar oligomers (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• (E)-2-Cyano-3-(5?-piperidin-1-yl-2,2?-bithien-5-yl)acrylic acid: A fluorescent probe for detecting prefibrillar oligomers (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/ejoc.201300241 (literal)

Alternative label

• Attanasio, Francesco; Bonaccorso, Carmela Maria; Bellia, Francesco; Cataldo, Sebastiano; Fortuna, Cosimo Gianluca; Musumarra, Giuseppe; Pignataro, Bruno; Rizzarelli, Enrico (2013)
  (E)-2-Cyano-3-(5?-piperidin-1-yl-2,2?-bithien-5-yl)acrylic acid: A fluorescent probe for detecting prefibrillar oligomers
  in European journal of organic chemistry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Attanasio, Francesco; Bonaccorso, Carmela Maria; Bellia, Francesco; Cataldo, Sebastiano; Fortuna, Cosimo Gianluca; Musumarra, Giuseppe; Pignataro, Bruno; Rizzarelli, Enrico (literal)

Pagina inizio

• 3635 (literal)

Pagina fine

• 3639 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/record/display.url?eid=2-s2.0-84879205787&origin=inward (literal)

Rivista

• European journal of organic chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 18 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Biostrutture e Bioimmagini-CNR; Dipartimento di Scienze Chimiche - Universita degli Studi di Catania; Universita degli Studi di Palermo (literal)

Titolo

• (E)-2-Cyano-3-(5?-piperidin-1-yl-2,2?-bithien-5-yl)acrylic acid: A fluorescent probe for detecting prefibrillar oligomers (literal)

Abstract

• The synthesis of (E)-2-cyano-3-(5?-piperidin-1-yl-2,2?-bithien- 5-yl)acrylic acid, a novel amyloid aggregation fluorescent probe, is reported. This new probe is able to monitor soluble oligomeric aggregates after 24 h, at which time Thioflavin T emission, commonly used to monitor amyloid fibril formation, remains unchanged. Atomic force microscopy, native polyacrylamide gel electrophoresis, and dynamic light scattering confirm that the earlier stages of aggregation are prefibrillar oligomeric species not possessing the amyloid structure. This new molecular scaffold expands the toolbox of fluorescent probes for the identification of prefibrillar oligomers, which is needed in studies aimed at the early detection of the soluble toxic aggregates that characterize the so-called protein misfolding diseases. (E)-2-Cyano-3-(5?-piperidin-1- yl-2,2?-bithien-5-yl)acrylic acid (p-TTCNAc) can be conveniently used as a fluorescent probe to identify prefibrillar oligomers of hen egg white lysozyme not detected by Thioflavin-T (ThT). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• FRANCESCO BELLIA (Unità di personale interno)
• FRANCESCO ATTANASIO (Persona)

Insieme di parole chiave

• Keywords of "(E)-2-Cyano-3-(5?-piperidin-1-yl-2,2?-bithien-5-yl)acrylic acid: A fluorescent probe for detecting prefibrillar oligomers" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR di

• FRANCESCO ATTANASIO (Persona)
• FRANCESCO BELLIA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of organic chemistry (Rivista)

Insieme di parole chiave di

• Keywords of "(E)-2-Cyano-3-(5?-piperidin-1-yl-2,2?-bithien-5-yl)acrylic acid: A fluorescent probe for detecting prefibrillar oligomers" (Insieme di parole chiave)