Basal and dynamic proinsulin-insulin relationship to assess beta-cell function during OGTT in metabolic disorders (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Basal and dynamic proinsulin-insulin relationship to assess beta-cell function during OGTT in metabolic disorders (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1152/ajpendo.00104.2002 (literal)

Alternative label

• Tura, A.; Pacini, G.; Kautzky-Willer, A.; Ludvik, B.; Prager, R.; Thomaseth, K. (2003)
  Basal and dynamic proinsulin-insulin relationship to assess beta-cell function during OGTT in metabolic disorders
  in American journal of physiology: endocrinology and metabolism
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Tura, A.; Pacini, G.; Kautzky-Willer, A.; Ludvik, B.; Prager, R.; Thomaseth, K. (literal)

Pagina inizio

• E155 (literal)

Pagina fine

• E162 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/12670835 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 285 (literal)

Rivista

• American journal of physiology: endocrinology and metabolism (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1, 2, 6: Metabolic Unit, Institute of Biomedical Engineering, National Research Council, 35127 Padua, Italy; 3, 4, 5: Division of Endocrinology and Metabolism, Department of Medicine 3, University of Vienna Medical School, A-1090 Vienna, Austria (literal)

Titolo

• Basal and dynamic proinsulin-insulin relationship to assess beta-cell function during OGTT in metabolic disorders (literal)

Abstract

• The fasting proinsulin-to-insulin ratio is a currently used marker of ?-cell dysfunction. This ratio is calculated at the basal condition, but its behavior in dynamic conditions, i.e., during glucose stimulation, could be more informative. Given the different kinetics of the peptides, a mathematical model was necessary to analyze the oral glucose tolerance test (OGTT) data of insulin, C-peptide, and proinsulin in 55 healthy (NGT), 30 impaired glucose-tolerant (IGT), and 31 type 2 diabetic (T2DM) subjects. The model provided for secretion and disappearance of the peptides and an index of ?-cell function under dynamic conditions. Total proinsulin secretion during the OGTT was not different (P ? 0.053) among NGT (0.17 ? 0.01 mmol/l in 3 h), IGT (0.22 ? 0.02), and T2DM (0.21 ? 0.02) subjects. The proinsulin-to-insulin molar ratio measured from basal samples was higher (P ? 0.0001) in T2DM (0.39 ? 0.05) than in NGT (0.14 ? 0.01) and IGT (0.13 ? 0.02) subjects, and similar results (P ? 0.003) were found by the dynamic index (0.27 ? 0.04, 0.14 ? 0.01, 0.15 ? 0.01 in T2DM, NGT, IGT subjects, respectively). The basal ratio significantly correlated with the dynamic index, and the regression line slope was lower than 1 (0.43 ? 0.08, 0.61 ? 0.10, and 0.56 ? 0.03 in NGT, IGT, and T2DM subjects, respectively, P ? 0.0001). Impaired ?-cell function in T2DM could then be indicated by proinsulin-to-insulin indexes at both basal and dynamic phases (literal)

Prodotto di

• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni (IEIIT) (Istituto)
• Institute of biomedical engineering (ISIB) (Istituto)

Autore CNR

• ANDREA TURA (Unità di personale interno)
• GIOVANNI PACINI (Unità di personale interno)
• KARL THOMASETH (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Basal and dynamic proinsulin-insulin relationship to assess beta-cell function during OGTT in metabolic disorders" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni (IEIIT) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• KARL THOMASETH (Unità di personale interno)
• GIOVANNI PACINI (Unità di personale interno)
• ANDREA TURA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• American journal of physiology: endocrinology and metabolism (Rivista)

Insieme di parole chiave di

• Keywords of "Basal and dynamic proinsulin-insulin relationship to assess beta-cell function during OGTT in metabolic disorders" (Insieme di parole chiave)