A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds. (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1093/nar/gkv006 (literal)

Alternative label

• Erica Salvati1,+, Angela Rizzo1,+, Sara Iachettini1, Pasquale Zizza1, Chiara Cingolani1, Carmen D'Angelo1, Manuela Porru1, Chiara Mondello2, Aurora Aiello3,4, Antonella Farsetti3,4, Eric Gilson5,6, Carlo Leonetti1 and Annamaria Biroccio1,* (2015)
  A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.
  in Nucleic acids research (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Erica Salvati1,+, Angela Rizzo1,+, Sara Iachettini1, Pasquale Zizza1, Chiara Cingolani1, Carmen D'Angelo1, Manuela Porru1, Chiara Mondello2, Aurora Aiello3,4, Antonella Farsetti3,4, Eric Gilson5,6, Carlo Leonetti1 and Annamaria Biroccio1,* (literal)

Rivista

• Nucleic acids research (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy, 2Istituto di Genetica Molecolare, National Research Council (CNR), Pavia, Italy, 3Institute of Cell Biology and Neurobiology (IBCN), CNR Rome, Italy, 4Department of Experimental Oncology, Regina Elena National Cancer Institute, Rome, Italy, 5Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR7284/INSERM U1081, University of Nice, Nice, France and 6Department of Medical Genetics, Archet 2 Hospital, CHU of Nice, Nice, France (literal)

Titolo

• A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds. (literal)

Abstract

• Here, with the aim of obtaining insight into the intriguing selectivity of G-quadruplex (G4) ligands toward cancer compared to normal cells, a genetically controlled system of progressive transformation in human BJ fibroblasts was analyzed. Among the different comparative evaluations, we found a progressive increase of DNA damage response (DDR) markers throughout the genome from normal toward immortalized and transformed cells. More interestingly, sensitivity to G4 ligands strongly correlated with the presence of a basal level of DNA damage, including at the telomeres, where the chromosome ends were exposed to the DDR without concurrent induction of DNA repair activity, as revealed by the lack of 53BP1 recruitment and telomere aberrations. The link between telomere uncapping and the response to G4 stabilization was directly assessed by showing that a partial TRF2 depletion, causing a basal level of telomere localized DDR, rendered telomerized fibroblasts prone to G4-induced telomere damage and anti-proliferative defects. Taken together these data strongly indicate that the presence of a basal level of telomere-associated DDR is a determinant of susceptibility to G4 stabilization. (literal)

Prodotto di

• Studio di pathway coinvolti nella progressione tumorale (ME.P05.005.002) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• CHIARA MONDELLO (Unità di personale interno)
• ANTONELLA FARSETTI (Persona)
• AURORA AIELLO (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Studio di pathway coinvolti nella progressione tumorale (ME.P05.005.002) (Modulo)

Autore CNR di

• ANTONELLA FARSETTI (Persona)
• CHIARA MONDELLO (Unità di personale interno)
• AURORA AIELLO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nucleic acids research (Rivista)