miR-34a regulates cell proliferation, morphology and function of newborn neurons resulting in improved behavioural outcomes (Articolo in rivista)

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  • miR-34a regulates cell proliferation, morphology and function of newborn neurons resulting in improved behavioural outcomes (Articolo in rivista) (literal)
Anno
  • 2015-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/cddis.2014.589. (literal)
Alternative label
  • Mollinari C, Racaniello M, Berry A, Pieri M, de Stefano MC, Cardinale A, Zona C, Cirulli F, Garaci E, Merlo D. (2015)
    miR-34a regulates cell proliferation, morphology and function of newborn neurons resulting in improved behavioural outcomes
    in Cell death and disease; Nature Publishing Group, London (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mollinari C, Racaniello M, Berry A, Pieri M, de Stefano MC, Cardinale A, Zona C, Cirulli F, Garaci E, Merlo D. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.nature.com/cddis/journal/v6/n1/full/cddis2014589a.html (literal)
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Note
  • Google Scholar (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1] Institute of Translational Pharmacology, National Research Council, Rome, Italy [2] Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy. 2Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy. 31] Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome, Italy [2] Department of System Medicine, University of Rome 'Tor Vergata', Rome, Italy. 4IRCCS San Raffaele Pisana, Rome, Italy. 5Department of System Medicine, University of Rome 'Tor Vergata', Rome, Italy. (literal)
Titolo
  • miR-34a regulates cell proliferation, morphology and function of newborn neurons resulting in improved behavioural outcomes (literal)
Abstract
  • miR-34a is involved in the regulation of the fate of different cell types. However, the mechanism by which it controls the differentiation programme of neural cells remains largely unknown. Here, we investigated the role of miR-34a in neurogenesis and maturation of developing neurons and identified Doublecortin as a new miR-34a target. We found that the overexpression of miR-34a in vitro significantly increases precursor proliferation and influences morphology and function of developing neurons. Indeed, miR-34a overexpressing neurons showed a decreased expression of several synaptic proteins and receptor subunits, a decrement of NMDA-evoked current density and, interestingly, a more efficient response to synaptic stimulus. In vivo, miR-34a overexpression showed stage-specific effects. In neural progenitors, miR-34a overexpression promoted cell proliferation, in migratory neuroblasts reduced the migration and in differentiating newborn neurons modulated process outgrowth and complexity. Importantly, we found that rats overexpressing miR-34a in the brain have better learning abilities and reduced emotionality. (literal)
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