http://www.cnr.it/ontology/cnr/individuo/prodotto/ID300190
Polyamines: Emerging players in bacteria-host interactions (Articolo in rivista)
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- Label
- Polyamines: Emerging players in bacteria-host interactions (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.ijmm.2013.06.008 (literal)
- Alternative label
Di Martino, Maria Letizia; Campilongo, Rosaria; Casalino, Mariassunta; Micheli, Gioacchino; Colonna, Bianca; Prosseda, Gianni (2013)
Polyamines: Emerging players in bacteria-host interactions
in International journal of medical microbiology (Print)
(literal)
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- Di Martino, Maria Letizia; Campilongo, Rosaria; Casalino, Mariassunta; Micheli, Gioacchino; Colonna, Bianca; Prosseda, Gianni (literal)
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- Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Biologia e Biotecnologie C. Darwin, Sapienza Università di Roma, Via dei Sardi 70, 00185 Roma, Italy;
Dipartimento di Biologia, Università Roma Tre, Viale G. Marconi 446, 00146 Roma, Italy;
Istituto di Biologia e Patologia Molecolari CNR, P. le A. Moro 5, 00185 Roma, Italy (literal)
- Titolo
- Polyamines: Emerging players in bacteria-host interactions (literal)
- Abstract
- Polyamines are small polycationic molecules found in almost all cells and associated with a wide variety of physiological processes. In recent years it has become increasingly clear that, in addition to core physiological functions, polyamines play a crucial role in bacterial pathogenesis. Considerable evidence has built up that bacteria have evolved mechanisms to turn these molecules to their own advantage and a novel standpoint to look at host-bacterium interactions emerges from the interplay among polyamines, host cells and infecting bacteria. In this review, we highlight how human bacterial pathogens have developed their own resourceful strategies to exploit polyamines or manipulate polyamine-related processes to optimize their fitness within the host. Besides contributing to a better understanding of the complex relationship between a pathogen and its host, acquisitions in this field have a significant potential towards the development of novel antibacterial therapeutic approaches. © 2013 Elsevier GmbH. (literal)
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