The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1042/BST20140264 (literal)

Alternative label

• Sechi, Stefano; Frappaolo, Anna; Belloni, Giorgio; Giansanti, Maria Grazia (2015)
  The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis
  in Biochemical Society transactions
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sechi, Stefano; Frappaolo, Anna; Belloni, Giorgio; Giansanti, Maria Grazia (literal)

Pagina inizio

• 117 (literal)

Pagina fine

• 121 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/record/display.url?eid=2-s2.0-84921750755&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 43 (literal)

Rivista

• Biochemical Society transactions (Rivista)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Consiglio Nazionale delle Ricerche, Istituto di Biologia e Patologia molecolari (literal)

Titolo

• The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis (literal)

Abstract

• Cytokinesis is an intricate process that requires an intimate interplay between actomyosin ring constriction and plasma membrane remodelling at the cleavage furrow. However, the molecular mechanisms involved in coupling the cytoskeleton dynamics with vesicle trafficking during cytokinesis are poorly understood. The highly conserved Golgi phosphoprotein 3 (GOLPH3), functions as a phosphatidylinositol 4-phosphate (PI4P) effector at the Golgi. Recent studies have suggested that GOLPH3 is up-regulated in several cancers and is associated with poor prognosis and more aggressive tumours. In Drosophila melanogaster, GOLPH3 localizes at the cleavage furrow of dividing cells, is required for successful cytokinesis and acts as a key molecule in coupling phosphoinositide (PI) signalling with actomyosin ring dynamics. Because cytokinesis failures have been linked with pre-malignant disease and cancer, the novel connection between GOLPH3 and cytokinesis imposes new fields of investigation in cancer biology and therapy. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)

Autore CNR

• ANNA FRAPPAOLO (Unità di personale esterno)
• STEFANO SECHI (Unità di personale esterno)
• MARIA GRAZIA GIANSANTI (Persona)

Insieme di parole chiave

• Parole chiave di "The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)

Autore CNR di

• MARIA GRAZIA GIANSANTI (Persona)
• STEFANO SECHI (Unità di personale esterno)
• ANNA FRAPPAOLO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biochemical Society transactions (Rivista)

Insieme di parole chiave di

• Parole chiave di "The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis" (Insieme di parole chiave)