Copper(II) coordination properties of the integrin ligand sequence PHSRN and its new beta-cyclodextrin conjugates (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Copper(II) coordination properties of the integrin ligand sequence PHSRN and its new beta-cyclodextrin conjugates (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jinorgbio.2012.04.002 (literal)

Alternative label

• Magri, Antonio; D'Alessandro, Franca; Distefano, Donatella A.; Campagna, Tiziana; Pappalardo, Giuseppe; Impellizzeri, Giuseppe; La Mendola, Diego (2012)
  Copper(II) coordination properties of the integrin ligand sequence PHSRN and its new beta-cyclodextrin conjugates
  in Journal of inorganic biochemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Magri, Antonio; D'Alessandro, Franca; Distefano, Donatella A.; Campagna, Tiziana; Pappalardo, Giuseppe; Impellizzeri, Giuseppe; La Mendola, Diego (literal)

Pagina inizio

• 15 (literal)

Pagina fine

• 24 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 113 (literal)

Rivista

• Journal of inorganic biochemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Biostrutture e Bioimmagini-CNR-Catania; Dipartimento di Scienze Chimiche, Università di Catania; Dipartimento di Scienze Farmaceutiche, Università di Pisa. (literal)

Titolo

• Copper(II) coordination properties of the integrin ligand sequence PHSRN and its new beta-cyclodextrin conjugates (literal)

Abstract

• The peptide sequence PHSRN is the second cell binding site of the human fibronectin protein, a glycoprotein which plays a critical adhesive role during development, tissue repair and angiogenesis. The copper(II) complexes with the peptide fragment PHSRN were characterized by potentiometric and UV-visible, CD, EPR spectroscopic methods. Thermodynamic and spectroscopic evidences indicate that at physiological pH, only one copper(II) complex species, [CuLH-2], is present and the metal ion is bound to one imidazole and two amide nitrogen atoms (N-Im, 2N(-)) in a tetrahedral distorted square planar coordination. Two new beta-cyclodextrin-ethylendiamino derivatives with the PHSRN covalently attached were synthesized as multitargeting molecules, able to have a site-specific recognition sequence, to interact with copper(II) ions and to be a potential carrier of hydrophobic drugs. Copper(II) complexes with these beta-cyclodextrin derivatives were characterized by means of potentiometric and spectroscopic techniques. The comparison of the experimental parameters determined at different pH values with those obtained for the parent peptide complex species, shows that at physiological pH the ethylendiamino-beta-CD moiety does not influence the peptide interaction with copper ions and the beta-CD hydrophobic cavity is not blocked, being available to host hydrophobic drugs such as naproxen. (C) 2012 Elsevier Inc. All rights reserved. (literal)

Prodotto di

• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• GIUSEPPE PAPPALARDO (Unità di personale interno)
• ANTONIO MAGRI' (Persona)
• TIZIANA CAMPAGNA (Persona)

Insieme di parole chiave

• Parole chiave di "Copper(II) coordination properties of the integrin ligand sequence PHSRN and its new beta-cyclodextrin conjugates" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIUSEPPE PAPPALARDO (Unità di personale interno)
• TIZIANA CAMPAGNA (Persona)
• ANTONIO MAGRI' (Persona)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Studio degli effetti di ioni metallici e membrane sulle proprietà conformazionali di sistemi amiloidogenici. (PM.P01.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of inorganic biochemistry (Rivista)

Insieme di parole chiave di

• Parole chiave di "Copper(II) coordination properties of the integrin ligand sequence PHSRN and its new beta-cyclodextrin conjugates" (Insieme di parole chiave)