http://www.cnr.it/ontology/cnr/individuo/prodotto/ID299401

Supratentorial and Infratentorial Damage in Spinocerebellar Ataxia 2: A Diffusion-Weighted MRI Study (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Supratentorial and Infratentorial Damage in Spinocerebellar Ataxia 2: A Diffusion-Weighted MRI Study (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1002/mds.25757 (literal)

Alternative label

Elena Salvatore(1), Enrico Tedeschi (2), Carmine Mollica (3,4), Caterina Vicidomini (3), Andrea Varrone (3), Anna Rita Daniela Coda (3), Arturo Brunetti (2), Marco Salvatore (2,3), Giuseppe De Michele (1), Alessandro Filla (1), Sabina Pappatà (3). (2014)
Supratentorial and Infratentorial Damage in Spinocerebellar Ataxia 2: A Diffusion-Weighted MRI Study
in Movement disorders
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Elena Salvatore(1), Enrico Tedeschi (2), Carmine Mollica (3,4), Caterina Vicidomini (3), Andrea Varrone (3), Anna Rita Daniela Coda (3), Arturo Brunetti (2), Marco Salvatore (2,3), Giuseppe De Michele (1), Alessandro Filla (1), Sabina Pappatà (3). (literal)

Pagina inizio

780 (literal)

Pagina fine

786 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

29 (literal)

Rivista

Movement disorders (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

6 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

(1) Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy (2) Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (3) Institute of Biostructure and Bioimaging, Naples, Italy (4) IRCCS Fondazione SDN, Naples, Italy (literal)

Titolo

Supratentorial and Infratentorial Damage in Spinocerebellar Ataxia 2: A Diffusion-Weighted MRI Study (literal)

Abstract

Spinocerebellar ataxia type 2 (SCA2) is an autosomal-dominant degenerative disorder that is neuropathologically characterized primarily by infratentorial damage, although less severe supratentorial involvement may contribute to the clinical manifestation. Diffusion-weighted imaging (DWI)-Magnetic Resonance Imaging (MRI) studies of SCA2 have enabled in vivo quantification of neurodegeneration in infratentorial regions, whereas supratentorial regions have been explored less thoroughly. We measured microstructural changes in both infratentorial and supratentorial regions in 13 SCA2 patients (9 men, 4 women; mean age, 50 +/- 12 years) and 15 controls (10 men, 5 women; mean age, 49 +/- 14 years) using DWI-MRI and correlated the DWI changes with disease severity and duration. Disease severity was evaluated using the International Cooperative Ataxia Rating Scale and the Inherited Ataxia Clinical Rating Scale. Cerebral diffusion trace ((D) over bar values were generated, and regions of interest (ROIs) and voxel-based analysis with Statistical Parametric Mapping (SPM) were used for data analysis. In SCA2 patients, ROI analysis and SPM confirmed significant increases in (D) over bar values in the pons, cerebellar white matter (CWM) and middle cerebellar peduncles. Moreover, SPM analysis revealed increased (D) over bar values in the right thalamus, bilateral temporal cortex/white matter, and motor cortex/pyramidal tract regions. Increased diffusivity in the frontal white matter (FWM) and the CWM was significantly correlated with ataxia severity. DWI-MRI revealed that both infratentorial and supratentorial microstructural changes may characterize SCA2 patients in the course of the disease and might contribute to the severity of the symptoms. (c) 2013 International Parkinson and Movement Disorder Society (literal)

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