Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ejmech.2015.01.047 (literal)

Alternative label

• Fabio Lolicato a, b, Antonio Raudino a, Danilo Milardi c, *, Carmelo La Rosa a, * (2015)
  Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study
  in European journal of medicinal chemistry (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Fabio Lolicato a, b, Antonio Raudino a, Danilo Milardi c, *, Carmelo La Rosa a, * (literal)

Pagina inizio

• 876 (literal)

Pagina fine

• 881 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 92 (literal)

Rivista

• European journal of medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Department of Chemical Sciences, University of Catania, Viale A. Doria 6, Catania I-95125, Italy b Department of Physics, Tampere University of Technology, P.O. Box 692, FI-33101 Tampere, Finland c Istituto di Biostrutture e Bioimmagini, CNR, Unità Organizzativa e di Supporto di Catania, Viale A. Doria 6, Catania I-95125, Italy (literal)

Titolo

• Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study (literal)

Abstract

• Amyloid aggregation of islet amyloid polypeptide (IAPP) in pancreatic tissues is a typical feature of type 2 diabetes mellitus. Resveratrol, a natural product extensively studied for its wide range of biological effects, has been shown to inhibit IAPP aggregation. However, the mechanism by which resveratrol inhibits IAPP aggregation is still far from complete elucidation. Now, an increasing knowledge of the mechanism of amyloid toxicity shifts the target of research towards the development of compounds which can prevent amyloid-mediated membrane damage rather than merely inhibit fiber formation. In this study we used all atom molecular dynamics to investigate the interaction of resveratrol with full-length human IAPP in a negatively charged membrane environment. Our results show that the presence of resveratrol induces the formation of secondary structures (sheets and helices) by inserting in a hydrophobic pocket between the interaction surface of two IAPP molecules in aqueous solution. On the other hand, resveratrol significantly perturbs the interaction of IAPP with negatively charged membranes by anchoring specific hydrophobic regions (23FGA25 and 32VGS34) of the peptide and forming a stable 1:2 IAPP:resveratrol complex at the water/membrane interphase. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Progettazione e sintesi di nuovi composti bioattivi e loro veicolazione sito specifica. (PM.P01.003.002) (Modulo)

Autore CNR

• DANILO MILARDI (Persona)

Insieme di parole chiave

• Keywords of "Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• DANILO MILARDI (Persona)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Progettazione e sintesi di nuovi composti bioattivi e loro veicolazione sito specifica. (PM.P01.003.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of medicinal chemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study" (Insieme di parole chiave)