http://www.cnr.it/ontology/cnr/individuo/prodotto/ID298809

AlteredGABAergicmarkers,increasedbinocularityandreducedplasticityinthevisualcortexofEngrailed-2knockoutmice (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

AlteredGABAergicmarkers,increasedbinocularityandreducedplasticityinthevisualcortexofEngrailed-2knockoutmice (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.3389/fncel.2014.00163 (literal)

Alternative label

Manuela Allegra1,2+, SachaGenovesi3+, MarikaMaggia3, MariaC.Cenni1, GiuliaZunino3, PaolaSgadò3, MatteoCaleo1?and YuriBozzi1,3* (2014)
AlteredGABAergicmarkers,increasedbinocularityandreducedplasticityinthevisualcortexofEngrailed-2knockoutmice
in Frontiers in cellular neuroscience
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Manuela Allegra1,2+, SachaGenovesi3+, MarikaMaggia3, MariaC.Cenni1, GiuliaZunino3, PaolaSgadò3, MatteoCaleo1?and YuriBozzi1,3* (literal)

Pagina inizio

1 (literal)

Pagina fine

15 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.frontiersin.org (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

8 (literal)

Rivista

Frontiers in cellular neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

16 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

163 (literal)

Note

Google Scholar (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Neuroscience Institute,NationalResearchCouncil(CNR),Pisa,Italy 2 LaboratoryofNeurobiology,ScuolaNormaleSuperiore,Pisa,Italy 3 LaboratoryofMolecularNeuropathology,CentreforIntegrativeBiology,UniversityofTrento,Mattarello,Trento,Italy (literal)

Titolo

AlteredGABAergicmarkers,increasedbinocularityandreducedplasticityinthevisualcortexofEngrailed-2knockoutmice (literal)

Abstract

ThematurationoftheGABAergicsystemisacrucialdeterminantofcorticaldevelopmentduringearlypostnatallife,whensensorycircuitsundergoaprocessofactivity-dependentrefinement.Analteredexcitatory/inhibitorybalancehasbeenproposedasapossiblepathogenicmechanismofautismspectrumdisorders(ASD).Thehomeobox-containingtranscriptionfactorEngrailed-2(En2)hasbeenassociatedtoASD,andEn2knockout(En2-/-)miceshowASD-likefeaturesaccompaniedbyapartiallossofcorticalGABAergicinterneurons.HerewestudiedGABAergicmarkersandcorticalfunctioninEn2-/-mice,byexploitingthewell-knownanatomicalandfunctionalfeaturesofthemousevisualsystem.En2isexpressedinthevisualcortexatpostnatalday30andduringadulthood.Whencomparedtoage-matchedEn2+/+controls,En2-/-miceshowedanincreasednumberofparvalbumin(PV+),somatostatin(SOM+),andneuropeptideY(NPY+)positiveinterneuronsinthevisualcortexatP30,andadecreasednumberofSOM+andNPY+interneuronsintheadult.Atbothages,thedifferencesindistinctinterneuronpopulationsobservedbetweenEn2+/+andEn2-/-micewerelayer-specific.AdultEn2-/-micedisplayedanormaleye-specificsegregationintheretino-geniculatepathway,andinvivoelectrophysiologicalrecordingsshowedanormaldevelopmentofbasicfunctionalproperties(acuity,responselatency,receptivefieldsize)oftheEn2-/-primaryvisualcortex.However,asignificantincreaseofbinocularitywasfoundinP30andadultEn2-/-mice,ascomparedtoage-matchedcontrols.DifferentlyfromwhatobservedinEn2+/+mice,theEn2-/-primaryvisualcortexdidnotrespondtoabriefmonoculardeprivationperformedbetweenP26andP29,duringtheso-called\"criticalperiod.\"ThesedatasuggestthatalteredGABAergiccircuitsimpactbaselinebinocularityandplasticityinEn2-/-mice,whileleavingothervisualfunctionalpropertiesunaffected. (literal)

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