Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bbr.2011.07.030 (literal)

Alternative label

• Russo, Emilio; Citraro, Rita; Scicchitano, Francesca; Urzino, Agostina; Marra, Rosario; Rispoli, Vincenzo; De Sarro, Giovambattista (2011)
  Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity
  in Behavioural brain research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Russo, Emilio; Citraro, Rita; Scicchitano, Francesca; Urzino, Agostina; Marra, Rosario; Rispoli, Vincenzo; De Sarro, Giovambattista (literal)

Pagina inizio

• 373 (literal)

Pagina fine

• 376 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 225 (literal)

Rivista

• Behavioural brain research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Magna Graecia University of Catanzaro; Inst Neurol Sci; Magna Graecia University of Catanzaro (literal)

Titolo

• Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity (literal)

Abstract

• To evaluate the effects of Vigabatrin (VGB) treatment, on both absence seizure and depressive-like behaviour development in the WAG/Rij rat model of absence seizures. Early long-term treatment with VGB could alter the development of absence pathology, by significantly reducing seizure generation and synchronization in contrast to its pro-absence effects observed after acute or subchronic administration. We have demonstrated the antidepressant effects of a sub-chronic treatment with VGB in both wistar and WAG/Rij rats. In contrast, following an early long-term treatment, VGB antidepressant effects were only observable in WAG/Rij rats. In conclusion, VGB has antiepileptogenic and antidepressant properties in the WAG/Rij rat model despite its pro-absence effects suggesting that epilepsy and depression, in this animal model, are directly related and that seizure development inhibition also reduces the development of depressive behaviour. (C) 2011 Elsevier B.V. All rights reserved. (literal)

Prodotto di

• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• ROSARIO MARRA (Persona)

Insieme di parole chiave

• Keywords of "Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of neurological sciences (ISN) (Istituto)

Autore CNR di

• ROSARIO MARRA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Behavioural brain research (Rivista)

Insieme di parole chiave di

• Keywords of "Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity" (Insieme di parole chiave)