In vitro study of AFB(1) and AFM(1) effects on human lymphoblastoid Jurkat T-cell model (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• In vitro study of AFB(1) and AFM(1) effects on human lymphoblastoid Jurkat T-cell model (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.3109/1547691X.2013.848250 (literal)

Alternative label

• Luongo, D.; Russo, R.; Balestrieri, A.; Marzocco, S.; Bergamo, P.; Severino, L. (2014)
  In vitro study of AFB(1) and AFM(1) effects on human lymphoblastoid Jurkat T-cell model
  in Journal of immunotoxicology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Luongo, D.; Russo, R.; Balestrieri, A.; Marzocco, S.; Bergamo, P.; Severino, L. (literal)

Pagina inizio

• 353 (literal)

Pagina fine

• 358 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 11 (literal)

Rivista

• Journal of immunotoxicology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Naples Federico II; NRC; University of Salerno (literal)

Titolo

• In vitro study of AFB(1) and AFM(1) effects on human lymphoblastoid Jurkat T-cell model (literal)

Abstract

• Aflatoxin B-1 (AFB(1)) is a mycotoxin produced by Aspergillus spp. that can occur as a natural contaminant in foods and feeds of vegetable origin. Post-ingestion, AFB(1) can be metabolized in the liver of mammals into hydroxylated aflatoxin M-1 (AFM(1)) that is excreted with milk. Although several studies have been carried out to evaluate effects of AFB(1) on the immune system, studies regarding AFM(1) are moreover lacking. The aim of the current study was to investigate effects of AFB(1) and AFM(1) on immune function using a lymphoblastoid Jurkat T-cell line as an experimental model. Both AFB(1) and AFM(1) produced significant decreases in Jurkat cell proliferation, whereas only minor effects were noted on interleukin (IL)-2 and interferon (IFN)-gamma cytokines mRNA expression in stimulated cells that had been pre-incubated with AFB(1) and AFM(1). Particularly, AFB(1), but not AFM(1), at the highest concentration (50 mu M) induced a marked increase in IL-8 mRNA expression. The results of the current study suggested the existence of a concentration threshold for AFB(1) and AFM(1) needed to exert biological activity on cell viability and innate immunity. (literal)

Prodotto di

• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Institute of food sciences (ISA) (Istituto)

Autore CNR

• PAOLO BERGAMO (Unità di personale interno)
• DIOMIRA LUONGO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "In vitro study of AFB(1) and AFM(1) effects on human lymphoblastoid Jurkat T-cell model" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)

Autore CNR di

• PAOLO BERGAMO (Unità di personale interno)
• DIOMIRA LUONGO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of immunotoxicology (Rivista)

Insieme di parole chiave di

• Keywords of "In vitro study of AFB(1) and AFM(1) effects on human lymphoblastoid Jurkat T-cell model" (Insieme di parole chiave)