Bioactivity of surface tethered Osteogenic Growth Peptide motifs (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Bioactivity of surface tethered Osteogenic Growth Peptide motifs (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/C4MD00112E (literal)

Alternative label

• Panseri S.; Russo L.; Montesi M.;Taraballi F.; Cunha C.; Marcacci M.; and Cipolla L. (2014)
  Bioactivity of surface tethered Osteogenic Growth Peptide motifs
  in MedChemComm (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Panseri S.; Russo L.; Montesi M.;Taraballi F.; Cunha C.; Marcacci M.; and Cipolla L. (literal)

Rivista

• MedChemComm (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Laboratory of Bioceramics and Bio-hybrid Composites, Institute of Science and Technology for Ceramics, National Research Council (ISTEC-CNR) Faenza 48018, Italy Laboratory of Biomechanics and Technology Innovation, Rizzoli Orthopaedic Institute, Bologna 40136, Italy Dept. of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano-Italy. (literal)

Titolo

• Bioactivity of surface tethered Osteogenic Growth Peptide motifs (literal)

Abstract

• Osteogenic Growth Peptide (OGP) motifs were tethered to SULFHYDRYL-BIND(TM) polystyrene plates tuning spatial presentation of the different functional domains. The effects of the different surface-tethered OGP motifs have been evaluated in mesenchymal stem cells (MSCs) osteogenesis. A culture medium without any osteogenic supplements was used in order to evaluate the OGP effect, avoiding any interference by additional factors. The motif YGFGG resulted to be the most interesting, strongly enhancing the expression of BMP2 that plays a fundamental role in bone regeneration. With this study we present new evidence of the role of OGP in osteogenesis and new insights into different OGP motifs able to act as best ligands for the design of innovative bioactive materials for osteogenesis promotion and regenerative medicine applications. (literal)

Prodotto di

• Processi di bio-mineralizzazione e sviluppo di compositi bio-ibridi nanostrutturati e funzionalizzati per la medicina rigenerativa (ME.P06.018.001) (Modulo)
• Institute of science and technology for ceramics (ISTEC) (Istituto)

Autore CNR

• SILVIA PANSERI (Unità di personale interno)
• MONICA MONTESI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of science and technology for ceramics (ISTEC) (Istituto)
• Processi di bio-mineralizzazione e sviluppo di compositi bio-ibridi nanostrutturati e funzionalizzati per la medicina rigenerativa (ME.P06.018.001) (Modulo)

Autore CNR di

• MONICA MONTESI (Unità di personale interno)
• SILVIA PANSERI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• MedChemComm (Rivista)