Enrichment of CD56(dim)KIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Enrichment of CD56(dim)KIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/ncomms6639 (literal)

Alternative label

• Ali, Talib Hassan; Pisanti, Simona; Ciaglia, Elena; Mortarini, Roberta; Anichini, Andrea; Garofalo, Cinzia; Tallerico, Rossana; Santinami, Mario; Gulletta, Elio; Ietto, Caterina; Galgani, Mario; Matarese, Giuseppe; Bifulco, Maurizio; Ferrone, Soldano; Colucci, Francesco; Moretta, Alessandro; Karre, Klas; Carbone, Ennio (2014)
  Enrichment of CD56(dim)KIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients
  in Nature communications
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ali, Talib Hassan; Pisanti, Simona; Ciaglia, Elena; Mortarini, Roberta; Anichini, Andrea; Garofalo, Cinzia; Tallerico, Rossana; Santinami, Mario; Gulletta, Elio; Ietto, Caterina; Galgani, Mario; Matarese, Giuseppe; Bifulco, Maurizio; Ferrone, Soldano; Colucci, Francesco; Moretta, Alessandro; Karre, Klas; Carbone, Ennio (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Nature communications (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Magna Graecia University of Catanzaro; Univ Thi Qar; University of Salerno; University of Salerno; Fondazione IRCCS Istituto Nazionale Tumori Milan; Fondazione IRCCS Istituto Nazionale Tumori Milan; University of Naples Federico II; IRCCS Multimed; Harvard University; University of Cambridge; University of Genoa; Karolinska Institutet (literal)

Titolo

• Enrichment of CD56(dim)KIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients (literal)

Abstract

• An important checkpoint in the progression of melanoma is the metastasis to lymph nodes. Here, to investigate the role of lymph node NK cells in disease progression, we analyze frequency, phenotype and functions of NK cells from tumour- infiltrated (TILN) and tumourfree ipsilateral lymph nodes (TFLN) of the same patients. We show an expansion of CD56(dim)CD57(dim)CD69+CCR7+KIR+NK cells in TILN. TILN NK cells display robust cytotoxic activity against autologous melanoma cells. In the blood of metastatic melanoma patients, the frequency of NK cells expressing the receptors for CXCL8 receptor is increased compared with healthy subjects, and blood NK cells also express the receptors for CCL2 and IL- 6. These factors are produced in high amount in TILN and in vitro switch the phenotype of blood NK cells from healthy donors to the phenotype associated with TILN. Our data suggest that the microenvironment of TILN generates and/or recruits a particularly effective NK cell subset. (literal)

Prodotto di

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)
• Correlazione tra sistema immunitario e sistema endocrino: modelli di alterata funzione del sistema immunitario come causa di patologie (SV.P16.001.001) (Modulo)

Autore CNR

• MARIO GALGANI (Persona)

Incoming links:

Prodotto

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)
• Correlazione tra sistema immunitario e sistema endocrino: modelli di alterata funzione del sistema immunitario come causa di patologie (SV.P16.001.001) (Modulo)

Autore CNR di

• MARIO GALGANI (Persona)
• http://www.cnr.it/ontology/cnr/individuo/unitaDiPersonaleEsterno/ID25545

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature communications (Rivista)