PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration. (Articolo in rivista)

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Label
  • PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration. (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Alternative label
  • Chiappetta G1, Valentino T2, Vitiello M2, Pasquinelli R1, Monaco M1, Palma G3, Sepe R4, Luciano A3, Pallante P2, Palmieri D5, Aiello C1, Rea D3, Losito SN1, Arra C3, Fusco A4, Fedele M2. (2014)
    PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration.
    in Oncotarget
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Chiappetta G1, Valentino T2, Vitiello M2, Pasquinelli R1, Monaco M1, Palma G3, Sepe R4, Luciano A3, Pallante P2, Palmieri D5, Aiello C1, Rea D3, Losito SN1, Arra C3, Fusco A4, Fedele M2. (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Department of Experimental Oncology, Functional Genomic Unit, National Cancer Institute \"Fondazione Giovanni Pascale\", IRCCS, 80131 Naples, Italy. 2Institute of Experimental Endocrinology and Oncology (IEOS), National Research Counsil (CNR), 80131 Naples, Italy. 3Animal Facility, National Cancer Institute \"Fondazione Giovanni Pascale\", IRCCS, 80131 Naples, Italy. 4Institute of Experimental Endocrinology and Oncology (IEOS), National Research Counsil (CNR), 80131 Naples, Italy. Department of Molecular Medicine and Medical Biotechnologies, University of Naples \"Federico II\", 80131 Naples, Italy. 5Departments of Molecular Virology, Immunology and Human Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA. (literal)
Titolo
  • PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration. (literal)
Abstract
  • PATZ1, a POZ-Zinc finger protein, is emerging as an important regulator of development and cancer, but its cancer-related function as oncogene or tumor-suppressor is still debated. Here, we investigated its possible role in thyroid carcinogenesis. We demonstrated PATZ1 is down-regulated in thyroid carcinomas compared to normal thyroid tissues, with an inverse correlation to the degree of cell differentiation. In fact, PATZ1 expression was significantly further down-regulated in poorly differentiated and anaplastic thyroid cancers compared to the papillary histotype, and it resulted increasingly delocalized from the nucleus to the cytoplasm proceeding from differentiated to undifferentiated thyroid carcinomas. Restoration of PATZ1 expression in three thyroid cancer-derived cell lines, all characterized by fully dedifferentiated cells, significantly inhibited their malignant behaviors, including in vitro proliferation, anchorage-independent growth, migration and invasion, as well as in vivo tumor growth. Consistent with recent studies showing a role for PATZ1 in the p53 pathway, we showed that ectopic expression of PATZ1 in thyroid cancer cells activates p53-dependent pathways opposing epithelial-mesenchymal transition and cell migration to prevent invasiveness. These results provide insights into a potential tumor-suppressor role of PATZ1 in thyroid cancer progression, and thus may have potential clinical relevance for the prognosis and therapy of thyroid cancer. (literal)
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