http://www.cnr.it/ontology/cnr/individuo/prodotto/ID2968
Influence of steady background gradients on the accuracy of molecular diffusion anisotropy measurements (Articolo in rivista)
- Type
- Label
- Influence of steady background gradients on the accuracy of molecular diffusion anisotropy measurements (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Alternative label
Rossi, C; Boss, A; Martirosian, P; Steidle, G; Capuani, S; Claussen, CD; Maraviglia, B; Schick, F (2008)
Influence of steady background gradients on the accuracy of molecular diffusion anisotropy measurements
in Magnetic resonance imaging
(literal)
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- Rossi, C; Boss, A; Martirosian, P; Steidle, G; Capuani, S; Claussen, CD; Maraviglia, B; Schick, F (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- \"[Rossi, Cristina; Boss, Andreas; Martirosian, Petros; Steidle, Guenter; Claussen, Claus D.; Schick, Fritz] Univ Tubingen, Dept Diagnost Radiol, Sect Expt Radiol, D-72076 Tubingen, Germany; [Rossi, Cristina; Capuani, Silvia; Maraviglia, Bruno] Univ Roma La Sapienza, CNR, INFM, CRS SOFT,Phys Dept, I-00185 Rome, Italy; [Maraviglia, Bruno] IRCCS Santa Lucia Fdn, I-00179 Rome, Italy (literal)
- Titolo
- Influence of steady background gradients on the accuracy of molecular diffusion anisotropy measurements (literal)
- Abstract
- Spatial susceptibility variations of body components lead to local gradients of the static magnetic field. Effects of such background gradients on fractional diffusion anisotropy (FA) measurements on whole-body magnetic resonance units operating at 1.5, 3.0 and 7.0 T were analyzed theoretically and experimentally. Analytical expressions were derived for the cases of diffusion occurring in isotropic media and in tissues with cylindrical symmetry (e.g., white matter tracts or skeletal musculature). Typical magnitudes of background gradient strengths were estimated from in vivo and in vitro measurements with B-0 field mapping sequences. Additionally, numerical simulations of magnetic field distributions and resulting field gradients were performed considering tissue-air interfaces in simplified geometrical arrangements. For media with isotropic diffusion, both measurements and analytical calculations showed increasing FA inaccuracy with stronger coupling between diffusion-encoding and background gradients. For cylindrical symmetry, FA values were estimated for a standard diffusion tensor imaging protocol in a realistic scenario. At 1 mm distance from a water-air inter-face, susceptibility-related background gradients amount to approximately 9 mT/m at 7 T and lead to a relative error of the measured FA of up to 48%. The error in the anisotropy assessment rises considerably with increasing field strength and must be taken into account especially for experimental and clinical studies on modem high-field systems. (c) 2008 Elsevier Inc. All rights reserved. (literal)
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