A Glycosylated, Labionin-Containing Lanthipeptide with Marked Antinociceptive Activity (Articolo in rivista)

Type
Label
  • A Glycosylated, Labionin-Containing Lanthipeptide with Marked Antinociceptive Activity (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/cb400692w (literal)
Alternative label
  • Iorio, Marianna; Sasso, Oscar; Maffioli, Sonia I.; Bertorelli, Rosalia; Monciardini, Paolo; Sosio, Margherita; Bonezzi, Fabiola; Summa, Maria; Brunati, Cristina; Bordoni, Roberta; Corti, Giorgio; Tarozzo, Glauco; Piomelli, Daniele; Reggiani, Angelo; Donadio, Stefano (2014)
    A Glycosylated, Labionin-Containing Lanthipeptide with Marked Antinociceptive Activity
    in ACS chemical biology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Iorio, Marianna; Sasso, Oscar; Maffioli, Sonia I.; Bertorelli, Rosalia; Monciardini, Paolo; Sosio, Margherita; Bonezzi, Fabiola; Summa, Maria; Brunati, Cristina; Bordoni, Roberta; Corti, Giorgio; Tarozzo, Glauco; Piomelli, Daniele; Reggiani, Angelo; Donadio, Stefano (literal)
Pagina inizio
  • 398 (literal)
Pagina fine
  • 404 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 9 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • NAICONS Srl; Istituto Italiano di Tecnologia - IIT; Consiglio Nazionale delle Ricerche (CNR) (literal)
Titolo
  • A Glycosylated, Labionin-Containing Lanthipeptide with Marked Antinociceptive Activity (literal)
Abstract
  • Among the growing family of ribosomally synthesized, post-translationally modified peptides, particularly intriguing are class III lanthipeptides containing the triamino acid labionin. In the course of a screening program aimed at finding bacterial cell wall inhibitors, we discovered a new lanthipeptide produced by an Actinoplanes sp. The molecule, designated NAI-112, consists of 22 amino acids and contains an N-terminal labionin and a C-terminal methyl-labionin. Unique among lanthipeptides, it carries a 6-deoxyhexose moiety N-linked to a tryptophan residue. Consistently, the corresponding gene cluster encodes, in addition to the LanKC enzyme characteristic of this lanthipeptide class, a glycosyl transferase. Despite possessing weak antibacterial activity, NAI-112 is effective in experimental models of nociceptive pain, reducing pain symptoms in mice in both the formalin and the chronic constriction injury tests. Thus, NAI-112 represents, after the labyrinthopeptins, the second example of a lanthipeptide effective against nociceptive pain. (literal)
Autore CNR

Incoming links:


Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it