Gut Microbiome in Down Syndrome (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Gut Microbiome in Down Syndrome (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1371/journal.pone.0112023 (literal)

Alternative label

• Biagi, Elena (a); Candela, Marco (a); Centanni, Manuela (a); Consolandi, Clarissa (b); Rampelli, Simone (a); Turroni, Silvia (a); Severgnini, Marco (b); Peano, Clelia (b); Ghezzo, Alessandro (c); Scurti, Maria (d); Salvioli, Stefano (d); Franceschi, Claudio (d); Brigidi, Patrizia (a) (2014)
  Gut Microbiome in Down Syndrome
  in PloS one
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Biagi, Elena (a); Candela, Marco (a); Centanni, Manuela (a); Consolandi, Clarissa (b); Rampelli, Simone (a); Turroni, Silvia (a); Severgnini, Marco (b); Peano, Clelia (b); Ghezzo, Alessandro (c); Scurti, Maria (d); Salvioli, Stefano (d); Franceschi, Claudio (d); Brigidi, Patrizia (a) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• PloS one (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (a) Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy. (b) Institute of Biomedical Technologies - Italian National Research Council, Milan, Italy. (c) Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy. (d) Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; Interdepartmental Centre \"L. Galvani\" (CIG), University of Bologna, Bologna, Italy. (literal)

Titolo

• Gut Microbiome in Down Syndrome (literal)

Abstract

• Premature aging seriously compromises the health status of Down Syndrome (DS) persons. Since human aging has been associated with a deterioration of the gut microbiota (GM)-host mutualism, here we investigated the composition of GM in DS. The observational study presented involved 17 adult DS persons. We characterized the GM structure by 454 pyrosequencing of the V4 region of the 16S rRNA gene. DS microbiome was compared with that of age-matched healthy non-trisomic adults enrolled in the same geographic area. The dominant GM fraction of DS persons showed an overall mutualistic immune-modulatory layout, comparable to that of healthy controls. This makes GM a possible factor counteracting the genetic determined acceleration of immune senescence in DS persons. However, we also found detectable signatures specific for DS among subdominant GM components, such as the increase of Parasporobacterium and Sutterella. In particular, the abundance of this last microorganism significantly correlated with the Aberrant Behavior Checklist (ABC) total score, allowing us to hypothesize a possible role for this microbial genus in behavioral features in DS. (literal)

Autore CNR

• MARCO SEVERGNINI (Unità di personale interno)
• CLELIA PEANO (Unità di personale interno)
• CLARISSA CONSOLANDI (Persona)

Incoming links:

Autore CNR di

• CLARISSA CONSOLANDI (Persona)
• MARCO SEVERGNINI (Unità di personale interno)
• CLELIA PEANO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)