http://www.cnr.it/ontology/cnr/individuo/prodotto/ID2967

In vivo F-19 MRI and F-19 MRS of F-19-labelled boronophenylalanine-fructose complex on a C6 rat glioma model to optimize boron neutron capture therapy (BNCT) (Articolo in rivista)

Type

Label

In vivo F-19 MRI and F-19 MRS of F-19-labelled boronophenylalanine-fructose complex on a C6 rat glioma model to optimize boron neutron capture therapy (BNCT) (Articolo in rivista) (literal)

Anno

Alternative label

Porcari, P; Capuani, S; D'Amore, E; Lecce, M; La Bella, A; Fasano, F; Campanella, R; Migneco, LM; Pastore, FS; Maraviglia, B (2008)
In vivo F-19 MRI and F-19 MRS of F-19-labelled boronophenylalanine-fructose complex on a C6 rat glioma model to optimize boron neutron capture therapy (BNCT)
in Physics in medicine and biology (Print)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Porcari, P; Capuani, S; D'Amore, E; Lecce, M; La Bella, A; Fasano, F; Campanella, R; Migneco, LM; Pastore, FS; Maraviglia, B (literal)

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

\"[Porcari, Paola; Capuani, Silvia] Univ Roma La Sapienza, Dept Phys, CNR INFM SOFT, I-00185 Rome, Italy; [Porcari, Paola; Capuani, Silvia; Maraviglia, Bruno] Enrico Fermi Ctr, Rome, Italy; [D'Amore, Emanuela] Ist Super Sanita, Serv Biotechnol & Anim Welf, I-00161 Rome, Italy; [Lecce, Mario; Pastore, Francesco Saverio] Univ Roma Tor Vergata, Dept Neurosci, Inst Neurosurg, Rome, Italy; [La Bella, Angela; Migneco, Luisa Maria] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy; [Fasano, Fabrizio] IRCCS, Santa Lucia Fdn, Neuroimaging Lab, Rome, Italy; [Campanella, Renzo] Univ Perugia, Dept Phys, I-06100 Perugia, Italy (literal)

Titolo

In vivo F-19 MRI and F-19 MRS of F-19-labelled boronophenylalanine-fructose complex on a C6 rat glioma model to optimize boron neutron capture therapy (BNCT) (literal)

Abstract

Boron neutron capture therapy (BNCT) is a promising binary modality used to treat malignant brain gliomas. To optimize BNCT effectiveness a non-invasive method is needed to monitor the spatial distribution of BNCT carriers in order to estimate the optimal timing for neutron irradiation. In this study, in vivo spatial distribution mapping and pharmacokinetics evaluation of the F-19-labelled boronophenylalanine (BPA) were performed using F-19 magnetic resonance imaging (F-19 MRI) and F-19 magnetic resonance spectroscopy (F-19 MRS). Characteristic uptake of F-19-BPA in C6 glioma showed a maximum at 2.5 h after compound infusion as confirmed by both F-19 images and F-19 spectra acquired on blood samples collected at different times after infusion. This study shows the ability of F-19 MRI to selectively map the bio-distribution of F-19-BPA in a C6 rat glioma model, as well as providing a useful method to perform pharmacokinetics of BNCT carriers. (literal)

Prodotto di