Virus-like particles produced in plants as potential vaccines (Articolo in rivista)

Type
Label
  • Virus-like particles produced in plants as potential vaccines (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1586/erv.12.147 (literal)
Alternative label
  • Scotti N.; Rybicki E.P. (2013)
    Virus-like particles produced in plants as potential vaccines
    in Expert review of vaccines (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Scotti N.; Rybicki E.P. (literal)
Pagina inizio
  • 211 (literal)
Pagina fine
  • 224 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84874058889&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR-IGV, National Research Council of Italy, Institute of Plant Genetics, Via Università 133, 80055 Portici, Napoli, Italy; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag X3, Rondebosch 7701, Cape Town, South Africa; Department of Molecular and Cell Biology, Upper Campus, University of Cape Town, Private Bag X3, Rondebosch 7701, Cape Town, South Africa (literal)
Titolo
  • Virus-like particles produced in plants as potential vaccines (literal)
Abstract
  • Virus-like particles (VLPs) have been produced as candidate vaccines in plants virtually since the introduction of biofarming. Even today, VLPs remain the best candidates for safe, immunogenic, efficacious and inexpensive vaccines. Well-characterized human animal viruses such as HBV, HCV, HIV and HPV, rotaviruses, norovirus, foot and mouth disease viruses and even influenza virus proteins have all been successfully investigated for VLP formation. Proteins have been produced in transgenic plants and via transient expression techniques; simple structures, structures depending on more than one protein, naked and enveloped particles have all been made. There have been multiple proofs of concept, more than a few proofs of efficacy, and several products moved into human trials. This review will cover the history of VLP production in plants, and will explore a few examples in detail to illustrate the potential of such a mode of production for human and animal medicine. © 2013 Expert Reviews Ltd. (literal)
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