Haptoglobin Modulates Beta-Amyloid Uptake by U-87 MG Astrocyte Cell Line (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Haptoglobin Modulates Beta-Amyloid Uptake by U-87 MG Astrocyte Cell Line (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s12031-014-0465-6 (literal)

Alternative label

• Maresca B.; Spagnuolo M.S.; Cigliano L. (2014)
  Haptoglobin Modulates Beta-Amyloid Uptake by U-87 MG Astrocyte Cell Line
  in Journal of molecular neuroscience
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Maresca B.; Spagnuolo M.S.; Cigliano L. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84911935650&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 54 (literal)

Rivista

• Journal of molecular neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 14 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Biologia, Università di Napoli Federico II, via Mezzocannone 8, Naples, 80134, Italy; Istituto per il Sistema Produzione Animale in Ambiente Mediterraneo, Consiglio Nazionale delle Ricerche, via Argine 1085, Naples, 80147, Italy (literal)

Titolo

• Haptoglobin Modulates Beta-Amyloid Uptake by U-87 MG Astrocyte Cell Line (literal)

Abstract

• Accumulation of beta-amyloid (A?) in the extracellular space, which is one of the hallmarks of Alzheimer's disease (AD), depends on the balance between its synthesis and clearance. The physiological role of extracellular chaperones, capable of affecting early events in the amyloid cascade, is increasingly being investigated by many research groups. Among these proteins, we focused on haptoglobin, which we recently found to form a complex with beta-amyloid in brain tissues or cerebrospinal fluids from patients with AD. We also previously reported that haptoglobin increases with age in rat hippocampus. Major aim of this study was to evaluate whether haptoglobin influences A? interaction with astrocytes and its internalization into these cells. Haptoglobin effect on A?-induced cell death was also explored. We report here that haptoglobin impairs A? uptake by human glioblastoma-astrocytoma cell line U-87 MG and limits the toxicity of this peptide on these cells. Of note, our data also show that A? can stimulate haptoglobin release by astrocyte cell lines. The study of the risk of developing AD should be focused not only on the analysis of A? but also on the level of critical ligands, such as haptoglobin, able to influence peptide aggregation or clearance. (literal)

Prodotto di

• Institute for animal production system in mediterranean environment (ISPAAM) (Istituto)
• Caratterizzazione, valorizzazione e sostenibilità di specie di rilevante interesse zootecnico mediante metodologie classiche e innovative (AG.P04.014.001) (Modulo)

Autore CNR

• MARIA STEFANIA SPAGNUOLO (Unità di personale interno)

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• Parole chiave di "Haptoglobin Modulates Beta-Amyloid Uptake by U-87 MG Astrocyte Cell Line" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA STEFANIA SPAGNUOLO (Unità di personale interno)

Prodotto

• Institute for animal production system in mediterranean environment (ISPAAM) (Istituto)
• Caratterizzazione, valorizzazione e sostenibilità di specie di rilevante interesse zootecnico mediante metodologie classiche e innovative (AG.P04.014.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of molecular neuroscience (Rivista)

Insieme di parole chiave di

• Parole chiave di "Haptoglobin Modulates Beta-Amyloid Uptake by U-87 MG Astrocyte Cell Line" (Insieme di parole chiave)