New perspectives on the use of nucleic acids in pharmacological applications: inhibitory action of extracellular self-DNA in biological systems (Articolo in rivista)

Type
Label
  • New perspectives on the use of nucleic acids in pharmacological applications: inhibitory action of extracellular self-DNA in biological systems (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s11101-014-9386-9 (literal)
Alternative label
  • Mazzoleni S.; Carteni F.; Bonanomi G.; Incerti G.; Chiusano M.L.; Termolino P.; Migliozzi A.; Senatore M.; Giannino F.; Rietkerk M.; Risitano A.; Lanzotti V. (2014)
    New perspectives on the use of nucleic acids in pharmacological applications: inhibitory action of extracellular self-DNA in biological systems
    in Phytochemistry reviews (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mazzoleni S.; Carteni F.; Bonanomi G.; Incerti G.; Chiusano M.L.; Termolino P.; Migliozzi A.; Senatore M.; Giannino F.; Rietkerk M.; Risitano A.; Lanzotti V. (literal)
Pagina inizio
  • 937 (literal)
Pagina fine
  • 946 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84912053493&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 13 (literal)
Rivista
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  • 4 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Agraria, University of Naples Federico II, Via Università 100, Portici, NA, 80055, Italy; CNR-IGV, Istituto di Genetica Vegetale, Via Università 133, Portici, NA, 80055, Italy; Department of Environmental Sciences, Utrecht University, PO Box 80115, Utrecht, 3508 TC, Netherlands; Dipartimento di Medicina clinica e Chirurgia, University of Naples Federico II, Via S. Pansini 5, Naples, 80131, Italy (literal)
Titolo
  • New perspectives on the use of nucleic acids in pharmacological applications: inhibitory action of extracellular self-DNA in biological systems (literal)
Abstract
  • The research for new products against pathogens, parasites and infesting species, in both agriculture and medicine, implies huge and increasing scientific, industrial and economic efforts. Traditional approaches are based on random screening procedures searching for bioactive compounds. However, the success of such methodologies in most cases has been strongly limited by side-effects of the potential new drugs, especially toxicity and pharmacological resistance. The use of nucleic acids in drug development has been introduced searching for target-specific effect. In addition, a recent discovery revealed that randomly fragmented extracellular self-DNA may act as highly species-specific inhibitory product for different species, suggesting an unprecedented use of DNA for biological control. On this base, a new scenario of pharmacological applications is discussed. (literal)
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