BAT2 AND BAT3 POLYMORPHISMS AS NOVEL GENETIC RISK FACTORS FOR REJECTION AFTER HLA-RELATED STEM CELL TRANSPLANTATION (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• BAT2 AND BAT3 POLYMORPHISMS AS NOVEL GENETIC RISK FACTORS FOR REJECTION AFTER HLA-RELATED STEM CELL TRANSPLANTATION (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/bmt.2014.177 (literal)

Alternative label

• Piras, Ignazio S.; Angius, Andrea; Andreani, Marco; Testi, Manuela; Floris, Matteo; Marktel, Sarah; Ciceri, Fabio; La Nasa, Giorgio; Fleischhauer, Katharina; Roncarolo, Maria Grazia; Bulfone, Alessandro; Bacchetta, Rosa; Gregori, Silvia (2014)
  BAT2 AND BAT3 POLYMORPHISMS AS NOVEL GENETIC RISK FACTORS FOR REJECTION AFTER HLA-RELATED STEM CELL TRANSPLANTATION
  in Tissue antigens
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Piras, Ignazio S.; Angius, Andrea; Andreani, Marco; Testi, Manuela; Floris, Matteo; Marktel, Sarah; Ciceri, Fabio; La Nasa, Giorgio; Fleischhauer, Katharina; Roncarolo, Maria Grazia; Bulfone, Alessandro; Bacchetta, Rosa; Gregori, Silvia (literal)

Pagina inizio

• 58 (literal)

Pagina fine

• 58 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 84 (literal)

Rivista

• Tissue antigens (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Crs4; Consiglio Nazionale delle Ricerche (CNR); IME Fdn; Osped San Raffaele IRCCS; University of Cagliari; Vita-Salute San Raffaele University; San Raffaele Telethon Inst Gene Therapy HSR TIGET (literal)

Titolo

• BAT2 AND BAT3 POLYMORPHISMS AS NOVEL GENETIC RISK FACTORS FOR REJECTION AFTER HLA-RELATED STEM CELL TRANSPLANTATION (literal)

Abstract

• The genetic background of donor and recipient is an important factor determining the outcome of allogeneic hematopoietic SCT (allo-HSCT). We applied whole-genome analysis to investigate genetic variants-other than HLA class I and II-associated with negative outcome after HLA-identical sibling allo-HSCT in a cohort of 110 ?-Thalassemic patients. We identified two single-nucleotide polymorphisms (SNPs) in BAT2 (A/G) and BAT3 (T/C) genes, SNP rs11538264 and SNP rs10484558, both located in the HLA class III region, in strong linkage disequilibrium between each other (R(2)=0.92). When considered as single SNP, none of them reached a significant association with graft rejection (nominal P<0.00001 for BAT2 SNP rs11538264, and P<0.0001 for BAT3 SNP rs10484558), whereas the BAT2/BAT3 A/C haplotype was present at significantly higher frequency in patients who rejected as compared to those with functional graft (30.0% vs 2.6%, nominal P=1.15 × 10(-8); and adjusted P=0.0071). The BAT2/BAT3 polymorphisms and specifically the A/C haplotype may represent a novel immunogenetic factor associated with graft rejection in patients undergoing allo-HSCT. (literal)

Prodotto di

• SEQUENZIAMENTO ESTENSIVO DI ACIDI NUCLEICI DI PIATTAFORME DI ULTIMA GENERAZIONE PER LA DELUCIDAZIONE DI TRATTI E MALATTIE COMUNI E RARE (ME.P05.017.004) (Modulo)
• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)

Autore CNR

• ANDREA ANGIUS (Unità di personale interno)

Incoming links:

Autore CNR di

• ANDREA ANGIUS (Unità di personale interno)

Prodotto

• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)
• SEQUENZIAMENTO ESTENSIVO DI ACIDI NUCLEICI DI PIATTAFORME DI ULTIMA GENERAZIONE PER LA DELUCIDAZIONE DI TRATTI E MALATTIE COMUNI E RARE (ME.P05.017.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Tissue antigens (Rivista)