A star polymer based on a polyethylene glycol with a porphyrinic core as a photosensitizing agent for application in photodynamic therapy: tests in vitro on human erythrocytes (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A star polymer based on a polyethylene glycol with a porphyrinic core as a photosensitizing agent for application in photodynamic therapy: tests in vitro on human erythrocytes (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/c3ra47913g (literal)

Alternative label

• Mineo, Placido; Faggio, Caterina; Micali, Norberto; Scamporrino, Emilio; Villari, Valentina (2014)
  A star polymer based on a polyethylene glycol with a porphyrinic core as a photosensitizing agent for application in photodynamic therapy: tests in vitro on human erythrocytes
  in RSC advances
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mineo, Placido; Faggio, Caterina; Micali, Norberto; Scamporrino, Emilio; Villari, Valentina (literal)

Pagina inizio

• 19389 (literal)

Pagina fine

• 19395 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 4 (literal)

Rivista

• RSC advances (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 37 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR-IPCF Istituto per I Processi Chimico-Fisici University of Catania- Dipartimento di Scienze Chimiche University of Messina (literal)

Titolo

• A star polymer based on a polyethylene glycol with a porphyrinic core as a photosensitizing agent for application in photodynamic therapy: tests in vitro on human erythrocytes (literal)

Abstract

• In this study, human erythrocytes were used to assess the cytotoxicity of an uncharged, water-soluble and bio-compatible porphyrin system [the 5,10,15,20-tetrakis-p-(omega-methoxypolyethyleneoxyphenyl) porphyrin, H-2-P], which has the potential to act as a photosensitizing agent in photodynamic therapy (PDT). By investigating the cytotoxicity effects under controlled conditions, at different porphyrin concentrations and upon increasing irradiation times, the data in the absence and in the presence of H-2-P were compared. It was shown that the H-2-P system, without the assistance of any additional carrier, is easily internalized into cells, unlike the process which occurs for charged porphyrins. Incubation of red blood cells with H-2-P resulted in non-cytotoxicity in control conditions but, under irradiation, the cytotoxicity increased significantly at 20 mu M of porphyrin; it further increased at 40 mu M, reaching total cell death at 80 mu M. These results suggest that, as already observed for other cellular species, PDT-mediated oxidative stress occurs. (literal)

Prodotto di

• Struttura e Dinamica in Sistemi Dispersi (MD.P01.014.007) (Modulo)
• Istituto per i processi chimico-fisici (IPCF) (Istituto)

Autore CNR

• VALENTINA VILLARI (Persona)
• PLACIDO GIUSEPPE MINEO (Persona)
• NORBERTO LIBORIO MICALI (Persona)

Incoming links:

Prodotto

• Istituto per i processi chimico-fisici (IPCF) (Istituto)
• Struttura e Dinamica in Sistemi Dispersi (MD.P01.014.007) (Modulo)

Autore CNR di

• NORBERTO LIBORIO MICALI (Persona)
• VALENTINA VILLARI (Persona)
• PLACIDO GIUSEPPE MINEO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• RSC advances (Rivista)