SNP-based linkage analysis in extended pedigrees: Comparison between two alternative approaches (Articolo in rivista)

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Label
  • SNP-based linkage analysis in extended pedigrees: Comparison between two alternative approaches (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1159/000360623 (literal)
Alternative label
  • Saint-Pierre A.; D'elia Y.; Ciullo M.; Pramstaller P.P.; Pattaro C. (2014)
    SNP-based linkage analysis in extended pedigrees: Comparison between two alternative approaches
    in Human heredity
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Saint-Pierre A.; D'elia Y.; Ciullo M.; Pramstaller P.P.; Pattaro C. (literal)
Pagina inizio
  • 27 (literal)
Pagina fine
  • 37 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84902926519&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 78 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • INSERM U1078, Etablissement Français du Sang, FR-29218 Brest Cedex 2, France; Center for Biomedicine, European Academy of Bolzano (EURAC), Bolzano, Italy; Affiliated Institute of the University of Lübeck, Lübeck, Germany; Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR Naples, Naples, Italy; Department of Neurology, University of Lübeck, Lübeck, Germany; Department of Neurology, Central Hospital, Bolzano, Italy (literal)
Titolo
  • SNP-based linkage analysis in extended pedigrees: Comparison between two alternative approaches (literal)
Abstract
  • Background: Linkage analysis on extended pedigrees is often challenged by the high computational demand of exact identity-by-descent (IBD) matrix reconstruction. When such an analysis becomes not feasible, two alternative solutions are contrasted: a full pedigree analysis based on approximate IBD estimation versus a pedigree splitting followed by exact IBD estimation. A multiple splitting (MS) approach, which combines linkage results across different splitting configurations, has been proposed to increase the power of single-split solutions. Methods: To assess whether MS can achieve a comparable power to a full pedigree analysis, we compared the power of linkage on a very large pedigree in both simulated and real-case scenarios, using variance components linkage analysis of a dense SNP array. Results: Our results confirm that the power to detect linkage is affected by the pedigree size. The MS approach showed higher power than the single-split analysis, but it was substantially less powerful than the full pedigree approach in both scenarios, at any level of significance and variance explained by a quantitative trait locus. Conclusion: The MS approach should always be preferred to analyses based on a single split but, when adequate computational resources are available, a full pedigree analysis is better than the MS analysis. Rather than focusing on how to best split a pedigree, it might be more valuable to identify computational solutions that can make the IBD estimation of dense-marker maps practically feasible, thus allowing a full pedigree analysis. © 2014 S. Karger AG, Basel. (literal)
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