Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response to antiepileptic drug treatment in temporal lobe epilepsy. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response to antiepileptic drug treatment in temporal lobe epilepsy. (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.seizure.2014.09.010 (literal)

Alternative label

• Ida Manna a, Antonio Gambardella b, Angelo Labate b, Laura Mumoli b, Edoardo Ferlazzo c, Franco Pucci b, Umberto Aguglia b,c, Aldo Quattrone a,b (2015)
  Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response to antiepileptic drug treatment in temporal lobe epilepsy.
  in Seizure (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ida Manna a, Antonio Gambardella b, Angelo Labate b, Laura Mumoli b, Edoardo Ferlazzo c, Franco Pucci b, Umberto Aguglia b,c, Aldo Quattrone a,b (literal)

Pagina inizio

• 124 (literal)

Pagina fine

• 126 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 24 (literal)

Rivista

• Seizure (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 3 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a. Institute of Molecular Bioimaging and Physiology (IBFM), Section of Germaneto, National Research Council, Catanzaro, Italy b. Institute of Neurology, University ''Magna Graecia'', Germaneto, Catanzaro, Italy c. Regional Epilepsy Centre, Hospital of Reggio Calabria, Reggio Calabria, Italy (literal)

Titolo

• Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response to antiepileptic drug treatment in temporal lobe epilepsy. (literal)

Abstract

• PURPOSE: A synonymous C to T variant at position 3435 (c.3435C>T) is one common polymorphism of the multidrug resistant 1 (MDR1) gene, which encodes the major transmembrane efflux transporter P-glycoprotein. It has been suggested that this polymorphism, and more specifically the 3435CC genotype, may be associated with the response to antiepileptic drug treatment. Here we wished to examine the role of such a candidate variant in a cohort of 175 patients (98 women and 76 men; mean±SD age: 47.90±17.64) with temporal lobe epilepsy (TLE). METHODS: Patients were classified according to whether they had drug-responsive (n=134) or drug-resistant (n=41) epilepsy. We also enrolled 175 healthy controls (93 women and 82 men; mean±SD age: 72.5±6.8), matched for sex and ethnicity. RESULTS: Patients and controls were genotyped for detection of the 3435C>T polymorphism, but the analysis showed no significant association between the CC genotype and the risk of drug-resistant epilepsy. CONCLUSION: These findings rule out the MDR1 c.3435C>T polymorphism having a major role or increasing the risk of drug-resistance suggesting a revision is required to determine the contribution of this polymorphism in predicting drug response in epilepsy. (literal)

Prodotto di

• Neuroimaging clinico dei disordini neurodegenerativi del movimento (ME.P02.028.001) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• IDA MANNA (Persona)

Insieme di parole chiave

• Keywords of "Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response to antiepileptic drug treatment in temporal lobe epilepsy." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• http://www.cnr.it/ontology/cnr/individuo/unitaDiPersonaleEsterno/ID25089
• IDA MANNA (Persona)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Neuroimaging clinico dei disordini neurodegenerativi del movimento (ME.P02.028.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Seizure (Rivista)

Insieme di parole chiave di

• Keywords of "Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response to antiepileptic drug treatment in temporal lobe epilepsy." (Insieme di parole chiave)