http://www.cnr.it/ontology/cnr/individuo/prodotto/ID294584

Assessment and clinical validation of margins for adaptive simultaneous integrated boost in neo-adjuvant radiochemotherapy for rectal cancer. (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Assessment and clinical validation of margins for adaptive simultaneous integrated boost in neo-adjuvant radiochemotherapy for rectal cancer. (Articolo in rivista) (literal)

Anno

2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/j.ejmp.2014.12.002 (literal)

Alternative label

Roberta Raso a, Elisa Scalco b, Claudio Fiorino a, Sara Broggi a, Giovanni Mauro Cattaneo a, Stefania Garelli d, Marco Pagliazzi a, Najla Slim c, Nadia di Muzio c, Giovanna Rizzo b, Riccardo Calandrino a, Paolo Passoni c (2015)
Assessment and clinical validation of margins for adaptive simultaneous integrated boost in neo-adjuvant radiochemotherapy for rectal cancer.
in Physica medica (Testo stamp.)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Roberta Raso a, Elisa Scalco b, Claudio Fiorino a, Sara Broggi a, Giovanni Mauro Cattaneo a, Stefania Garelli d, Marco Pagliazzi a, Najla Slim c, Nadia di Muzio c, Giovanna Rizzo b, Riccardo Calandrino a, Paolo Passoni c (literal)

Pagina inizio

167 (literal)

Pagina fine

72 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

31 (literal)

Rivista

Physica medica (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

2 (literal)

Note

PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Medical Physics, San Raffaele Scientific Institute, Milano, Italy. 2. Istituto di Bioimmagini e Fisiologia Molecolare, CNR, Segrate, Milano, Italy. 3. Medical Physics, San Raffaele Scientific Institute, Milano, Italy. Electronic address: fiorino.claudio@hsr.it. 4. Medical Physics, San Martino-IST Scientific Institute, Genova, Italy. 5. Radiotherapy, San Raffaele Scientific Institute, Milano, Italy. (literal)

Titolo

Assessment and clinical validation of margins for adaptive simultaneous integrated boost in neo-adjuvant radiochemotherapy for rectal cancer. (literal)

Abstract

PURPOSE: An adaptive concomitant boost (ACB) for the neo-adjuvant treatment of rectal cancer was clinically implemented. In this study population margins M(90,90) considering rectal deformation were derived for 10 consecutive patients treated at 18 × 2.3Gy with Helical Tomotherapy (HT) and prospectively validated on 20 additional patients treated with HT, delivering ACB in the last 6 fractions. METHODS: Sectorial margins M(90,90) of the whole and second treatment parts were assessed for 90% population through a method combining the 90% coverage probability maps of rectal positions (CPC90%) with 3D local distance measurements between the CPC90% and a reference rectal contour. M(90,90) were compared with the margins M(90,90)95%/99%, ensuring CPC90% coverage with 95%/99% confidence level. M(90,90) of the treatment second part were chosen as ACB margins which were clinically validated for each patient by means of %volume missing of CPC5/6 excluded by the ACB margins. RESULTS: The whole treatment M(90,90) ranged between 1.9 mm and 9 mm in the lower-posterior and upper-anterior sectors, respectively. Regarding ACB, M(90,90) were 7 mm in the anterior direction and <5 mm elsewhere. M(90,90)95%/99% did not significantly differ from M(90,90). The %volume excluded by the ACB margin was<2% for all male and <5% for 9/10 female patients. The dosimetry impact on R_adapt for the patients with the largest residual error was negligible. CONCLUSIONS: Local deformation measurements confirm an anisotropic motion of rectum once set-up error is rigidly corrected. Margins of 7 mm anterior and 5 mm elsewhere are adequate for ACB. Female patients show a slightly larger residual error. (literal)

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