MafB is a downstream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation (Articolo in rivista)

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  • MafB is a downstream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbamcr.2014.01.021 (literal)
Alternative label
  • Gemelli C.; Zanocco Marani T.; Bicciato S.; Mazza E.M.C.; Boraschi D.; Salsi V.; Zappavigna V.; Parenti S.; Selmi T.; Tagliafico E.; Ferrari S.; Grande A. (2014)
    MafB is a downstream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation
    in Biochimica et biophysica acta. Molecular cell research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gemelli C.; Zanocco Marani T.; Bicciato S.; Mazza E.M.C.; Boraschi D.; Salsi V.; Zappavigna V.; Parenti S.; Selmi T.; Tagliafico E.; Ferrari S.; Grande A. (literal)
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  • 955 (literal)
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  • 964 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84894497372&partnerID=q2rCbXpz (literal)
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  • 1843 (literal)
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  • 5 (literal)
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  • Scopu (literal)
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  • Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena, Italy; Immunobiology Unit, Institute of Biomedical Technologies, CNR, Pisa, Italy IBP - Istituto di biochimica delle proteine, CNR, Napoli, Italy (literal)
Titolo
  • MafB is a downstream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation (literal)
Abstract
  • In spite of the numerous reports implicating MafB transcription factor in the molecular control of monocyte-macrophage differentiation, the precise genetic program underlying this activity has been, to date, poorly understood. To clarify this issue, we planned a number of experiments that were mainly conducted on human primary macrophages. In this regard, a preliminary gene function study, based on MafB inactivation and over-expression, indicated MMP9 and IL-. 7R genes as possible targets of the investigated transcription factor. Bioinformatics analysis of their promoter regions disclosed the presence of several putative MARE elements and a combined approach of EMSA and luciferase assay subsequently demonstrated that expression of both genes is indeed activated by MafB through a direct transcription mechanism. Additional investigation, performed with similar procedures to elucidate the biological relevance of our observation, revealed that MafB is a downstream target of the IL-10/STAT3 signaling pathway, normally inducing the macrophage de-activation process. Taken together our data support the existence of a signaling cascade by which stimulation of macrophages with the IL-10 cytokine determines a sequential activation of STAT3 and MafB transcription factors, in turn leading to an up-regulated expression of MMP9 and IL-. 7R genes. © 2014 Elsevier B.V. (literal)
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