http://www.cnr.it/ontology/cnr/individuo/prodotto/ID294552
Concern-driven integrated approaches to nanomaterial testing and assessment - report of the NanoSafety Cluster Working Group 10 (Articolo in rivista)
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- Concern-driven integrated approaches to nanomaterial testing and assessment - report of the NanoSafety Cluster Working Group 10 (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.3109/17435390.2013.802387 (literal)
- Alternative label
Oomen, Agnes G.; Bos, Peter M. J.; Fernandes, Teresa F.; Hund-Rinke, Kerstin; Boraschi, Diana; Byrne, Hugh J.; Aschberger, Karin; Gottardo, Stefania; von der Kammer, Frank; Kuehnel, Dana; Hristozov, Danail; Marcomini, Antonio; Migliore, Lucia; Scott-Fordsmand, Janeck; Wick, Peter; Landsiedel, Robert (2014)
Concern-driven integrated approaches to nanomaterial testing and assessment - report of the NanoSafety Cluster Working Group 10
in Nanotoxicology (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Oomen, Agnes G.; Bos, Peter M. J.; Fernandes, Teresa F.; Hund-Rinke, Kerstin; Boraschi, Diana; Byrne, Hugh J.; Aschberger, Karin; Gottardo, Stefania; von der Kammer, Frank; Kuehnel, Dana; Hristozov, Danail; Marcomini, Antonio; Migliore, Lucia; Scott-Fordsmand, Janeck; Wick, Peter; Landsiedel, Robert (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Netherlands National Institute for Public Health & the Environment; Heriot Watt University; Fraunhofer Gesellschaft; Consiglio Nazionale delle Ricerche (CNR); Dublin Institute of Technology; Commiss European Communities; University of Vienna; Helmholtz Association; Universita Ca Foscari Venezia; University of Pisa; Aarhus University; Swiss Federal Laboratories for Materials Science & Technology (EMPA); BASF (literal)
- Titolo
- Concern-driven integrated approaches to nanomaterial testing and assessment - report of the NanoSafety Cluster Working Group 10 (literal)
- Abstract
- Bringing together topic-related European Union (EU)-funded projects, the so-called \"NanoSafety Cluster\" aims at identifying key areas for further research on risk assessment procedures for nanomaterials (NM). The outcome of NanoSafety Cluster Working Group 10, this commentary presents a vision for concern-driven integrated approaches for the (eco-)toxicological testing and assessment (IATA) of NM. Such approaches should start out by determining concerns, i.e., specific information needs for a given NM based on realistic exposure scenarios. Recognised concerns can be addressed in a set of tiers using standardised protocols for NM preparation and testing. Tier 1 includes determining physico-chemical properties, non-testing (e. g., structure-activity relationships) and evaluating existing data. In tier 2, a limited set of in vitro and in vivo tests are performed that can either indicate that the risk of the specific concern is sufficiently known or indicate the need for further testing, including details for such testing. Ecotoxicological testing begins with representative test organisms followed by complex test systems. After each tier, it is evaluated whether the information gained permits assessing the safety of the NM so that further testing can be waived. By effectively exploiting all available information, IATA allow accelerating the risk assessment process and reducing testing costs and animal use (in line with the 3Rs principle implemented in EU Directive 2010/63/EU). Combining material properties, exposure, biokinetics and hazard data, information gained with IATA can be used to recognise groups of NM based upon similar modes of action. Grouping of substances in return should form integral part of the IATA themselves. (literal)
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