Alum and Squalene-Oil-in-Water Emulsion enhance the titer and avidity of Anti-Ab antibodies induced by Multimeric Protein Antigen (i-11)E2, preserving the IgG1-skewed isotype distribution (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Alum and Squalene-Oil-in-Water Emulsion enhance the titer and avidity of Anti-Ab antibodies induced by Multimeric Protein Antigen (i-11)E2, preserving the IgG1-skewed isotype distribution (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1371/journal.pone.0101474 (literal)

Alternative label

• Mantile F, Trovato M, Santoni A, Barba P, Ottonello S, De Berardinis P, Prisco A (2014)
  Alum and Squalene-Oil-in-Water Emulsion enhance the titer and avidity of Anti-Ab antibodies induced by Multimeric Protein Antigen (i-11)E2, preserving the IgG1-skewed isotype distribution
  in PloS one
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mantile F, Trovato M, Santoni A, Barba P, Ottonello S, De Berardinis P, Prisco A (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101474 (literal)

Rivista

• PloS one (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Genetics and Biophysics, CNR, Napoli, Italy Institute of Protein Biochemistry, CNR, Napoli, Italy Department of Life Sciences, University of Parma, Parma, Italy (literal)

Titolo

• Alum and Squalene-Oil-in-Water Emulsion enhance the titer and avidity of Anti-Ab antibodies induced by Multimeric Protein Antigen (i-11)E2, preserving the IgG1-skewed isotype distribution (literal)

Abstract

• The development of active immunotherapy for Alzheimer's disease (AD) requires the identification of immunogens that can ensure a high titer antibody response toward A?, while minimizing the risks of adverse reactions. Multimeric protein (1-11)E2 induces a robust and persistent antibody response to A? in mice, when formulated in Freund's adjuvant. The goal of this translational study was to evaluate the immunogenicity of (1-11)E2 formulated in alum (Alhydrogel 2%), or in a squalene oil-in-water emulsion (AddaVax), or without adjuvant. A IgG1-skewed isotype distribution was observed for the anti-A? antibodies generated in mice immunized with either the non-adjuvanted or the adjuvanted vaccine, indicating that (1-11)E2 induces a Th2-like response in all tested conditions. Both Alhydrogel 2% and AddaVax enhanced the titer and avidity of the anti-A? response elicited by (1-11)E2. We conclude that (1-11)E2 is a promising candidate for anti-A? immunization protocols that include alum or squalene-oil-in-water emulsion, or no adjuvant. (literal)

Prodotto di

• Institute of protein biochemistry (IBP) (Istituto)
• DR. DE BERARDINIS: SV.P03.006 (SV.P14.003.001) (Modulo)

Autore CNR

• MARIA TROVATO (Unità di personale esterno)
• PIERGIUSEPPE DE BERARDINIS (Unità di personale interno)

Incoming links:

Prodotto

• Institute of protein biochemistry (IBP) (Istituto)
• DR. DE BERARDINIS: SV.P03.006 (SV.P14.003.001) (Modulo)

Autore CNR di

• PIERGIUSEPPE DE BERARDINIS (Unità di personale interno)
• MARIA TROVATO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)