Bioactivity of a family of chiral nonracemic aminobenzylnaphthols towards candida albicans (Articolo in rivista)

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Label
  • Bioactivity of a family of chiral nonracemic aminobenzylnaphthols towards candida albicans (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3390/molecules19045219 (literal)
Alternative label
  • Capozzi, Maria Annunziata M.; Cardellicchio, Cosimo; Magaletti, Angela; Bevilacqua, Antonio; Perricone, Marianne; Corbo Maria Rosaria (2014)
    Bioactivity of a family of chiral nonracemic aminobenzylnaphthols towards candida albicans
    in Molecules (Basel, Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Capozzi, Maria Annunziata M.; Cardellicchio, Cosimo; Magaletti, Angela; Bevilacqua, Antonio; Perricone, Marianne; Corbo Maria Rosaria (literal)
Pagina inizio
  • 5219 (literal)
Pagina fine
  • 5230 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84899552879&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 19 (literal)
Rivista
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  • 4 (literal)
Note
  • Scopu (literal)
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  • 1 Department of Chemistry, University of Bari, Via Orabona 4, 70125 Bari, Italy; CNR-ICCOM, at the Department of Chemistry, University of Bari, Via Orabona 4, 70125 Bari, Italy; Department of the Science of Agriculture, Food and Environment, University of Foggia, Via Napoli 25, 71122 Foggia, Italy (literal)
Titolo
  • Bioactivity of a family of chiral nonracemic aminobenzylnaphthols towards candida albicans (literal)
Abstract
  • Chiral nonracemic aminobenzylnaphthols were obtained by a Betti multicomponent reaction between 2-naphthol, aryl aldehydes and enantiopure arylethylamine. Moreover, some new aminobenzylnaphthols were synthesized by a similar reaction between 2-naphthol, aryl aldehydes and prolinol. These aminobenzylnaphthols, synthesized from different components and thus having different structural features, were tested as anti-yeast agents inhibiting Candida albicans. The effect towards the test strain was studied with a microdilution approach and three different concentrations (150, 300 and 450 ?g/mL) were tested. The best results were found for the aminobenzylnaphthols obtained from 1-naphthylethylamine and from natural prolinol. The use of the two-way ANOVA highlighted the better performances of the prolinol derivative among the differently structured aminobenzylnaphthols that were screened. The activity towards C. albicans of this prolinol derivative resulted to be interesting and could represent a promising alternative to overcome the problem of the strains resistant to the traditional antifungals. © 2014 by the authors; licensee MDPI, Basel, Switzerland. (literal)
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