Parkin regulates kainate receptors by interacting with the GluK2 subunit (Articolo in rivista)

Type
Label
  • Parkin regulates kainate receptors by interacting with the GluK2 subunit (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ncomms6182 (literal)
Alternative label
  • Maraschi, AnnaMaria; Ciammola, Andrea; Folci, Alessandra; Sassone, Francesca; Ronzitti, Giuseppe; Cappelletti, Graziella; Silani, Vincenzo; Sato, Shigeto; Hattori, Nobutaka; Mazzanti, Michele; Chieregatti, Evelina; Mulle, Christophe; Passafaro, Maria; Sassone, Jenny (2014)
    Parkin regulates kainate receptors by interacting with the GluK2 subunit
    in Nature communications
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Maraschi, AnnaMaria; Ciammola, Andrea; Folci, Alessandra; Sassone, Francesca; Ronzitti, Giuseppe; Cappelletti, Graziella; Silani, Vincenzo; Sato, Shigeto; Hattori, Nobutaka; Mazzanti, Michele; Chieregatti, Evelina; Mulle, Christophe; Passafaro, Maria; Sassone, Jenny (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 10 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IRCCS Ist Auxol Italiano; IRCCS Ist Auxologico Italiano; University of Milan; Istituto Italiano di Tecnologia - IIT; University of Milan; University of Milan; Juntendo University; Centre National de la Recherche Scientifique (CNRS) (literal)
Titolo
  • Parkin regulates kainate receptors by interacting with the GluK2 subunit (literal)
Abstract
  • Although loss-of-function mutations in the PARK2 gene, the gene that encodes the protein parkin, cause autosomal recessive juvenile parkinsonism, the responsible molecular mechanisms remain unclear. Evidence suggests that a loss of parkin dysregulates excitatory synapses. Here we show that parkin interacts with the kainate receptor (KAR) GluK2 subunit and regulates KAR function. Loss of parkin function in primary cultured neurons causes GluK2 protein to accumulate in the plasma membrane, potentiates KAR currents and increases KAR-dependent excitotoxicity. Expression in the mouse brain of a parkin mutant causing autosomal recessive juvenile parkinsonism results in GluK2 protein accumulation and excitotoxicity. These findings show that parkin regulates KAR function in vitro and in vivo, and suggest that KAR upregulation may have a pathogenetic role in parkin-related autosomal recessive juvenile parkinsonism. (literal)
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