Different effects of Alzheimer's peptide A beta(1-40) oligomers and fibrils on supported lipid membranes (Articolo in rivista)

Type
Label
  • Different effects of Alzheimer's peptide A beta(1-40) oligomers and fibrils on supported lipid membranes (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bpc.2013.07.010 (literal)
Alternative label
  • Canale, Claudio; Seghezza, Silvia; Vilasi, Silvia; Carrotta, Rita; Bulone, Donatella; Diaspro, Alberto; Biagio, Pier Luigi San; Dante, Silvia (2013)
    Different effects of Alzheimer's peptide A beta(1-40) oligomers and fibrils on supported lipid membranes
    in Biophysical chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Canale, Claudio; Seghezza, Silvia; Vilasi, Silvia; Carrotta, Rita; Bulone, Donatella; Diaspro, Alberto; Biagio, Pier Luigi San; Dante, Silvia (literal)
Pagina inizio
  • 23 (literal)
Pagina fine
  • 29 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 182 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto Italiano di Tecnologia - IIT; Consiglio Nazionale delle Ricerche (CNR) (literal)
Titolo
  • Different effects of Alzheimer's peptide A beta(1-40) oligomers and fibrils on supported lipid membranes (literal)
Abstract
  • Beta-amyloid (1-40) is one of the two most abundant species of amyloid-beta peptides present as fibrils in the extracellular senile plaques in the brain of Alzheimer's patients. Recently, the molecular aggregates constituting the early stage of fibril formation, i.e., oligomers and protofibrils, have been investigated as the main responsible for amyloid-beta cytotoxic effect. The molecular mechanism leading to neurodegeneration is still under debate, and it is common opinion that it may reside in the interaction between amyloid species and the neural membrane. In this investigation Atomic Force Microscopy and spectroscopy have been used to understand how structural (and mechanical) properties of POPC/POPS lipid bilayers, simulating the phospholipid composition and negative net charge of neuritic cell membranes, are influenced by the interaction with A beta(1-40), in different stages of the peptide aggregation. Substantial differences in the damage caused to the lipid bilayers have been observed, confirming the toxic effect exerted especially by A beta(1-40) prefibrillar oligomers. (c) 2013 Elsevier B.V. All rights reserved. (literal)
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